Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet' syndrome


Submitted: 13 November 2020
Accepted: 15 February 2021
Published: 17 March 2021
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Authors

  • Olga Vera-Lastra Internal Medicine Department, Hospital de Especialidades Centro Médico Nacional La Raza, IMSS, Mexico City; Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Arturo Olvera-Acevedo Internal Medicine Department, Hospital de Especialidades Centro Médico Nacional La Raza, IMSS, Mexico City; Universidad Nacional Autónoma de México, Mexico City, Mexico.
  • Nancy Pulido-Díaz Dermatology Department, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Marissa de Jesús Quintal-Ramírez 4Pathology Department, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Irvin Ordoñez-González Universidad Veracruzana, Veracruz, Mexico. https://orcid.org/0000-0001-7293-7132
  • Erik Cimé-Aké Internal Medicine Department, Hospital de Especialidades Centro Médico Nacional La Raza, IMSS, Mexico City; Universidad Nacional Autónoma de México, Mexico City, Mexico. https://orcid.org/0000-0002-7012-8419
  • María Pilar Cruz-Domínguez Universidad Nacional Autónoma de México, Mexico City; Translational Research Unit, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Gabriela Medina Universidad Nacional Autónoma de México, Mexico City; Research Division, Hospital de Especialidades Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social, Mexico City, Mexico. https://orcid.org/0000-0002-5891-8653

The Sweet’ syndrome, is an inflammatory skin disorder characterized by extensive infiltration of neutrophils in the dermis with extension to the subcutis, known as acute febrile neutrophilic dermatosis. It may occur as a paraneoplastic syndrome. To our knowledge, there are currently few reports about transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet syndrome in the literature. Herein we describe an unusual case in a young patient with these characteristics that evolved to a fatal outcome.


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Vera-Lastra, O., Olvera-Acevedo, A., Pulido-Díaz, N., Quintal-Ramírez, M. de J., Ordoñez-González, I., Cimé-Aké, E., Cruz-Domínguez, M. P., & Medina, G. (2021). Transformation of a myelodysplastic syndrome to acute myeloid leukemia and concurrent necrotizing Sweet’ syndrome. Dermatology Reports, 13(1). https://doi.org/10.4081/dr.2021.9017

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