Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia
https://doi.org/10.4081/dr.2024.9864
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Ataxia telangiectasia (AT) is a rare autosomal recessive primary immunodeficiency disorder (PID) resulting from a mutation in the ATM gene, which is involved in DNA repair. We describe the case of a young girl with cutaneous granulomas that developed after childhood vaccinations. Immunohistochemistry revealed granulomas induced by the rubella virus vaccine. This finding raises the question of live rubella vaccine strains safety in immunocompromised children.
van Os NJH, Jansen AFM, van Deuren M, Haraldsson A, van Driel NTM, Etzioni A, et al. Ataxia-telangiectasia: Immunodeficiency and survival. Clin Immunol. 2017 May;178:45–55. DOI: https://doi.org/10.1016/j.clim.2017.01.009
Rothblum-Oviatt C, Wright J, Lefton-Greif MA, McGrath-Morrow SA, Crawford TO, Lederman HM. Ataxia telangiectasia: a review. Orphanet J Rare Dis. 2016 Dec;11(1):159. DOI: https://doi.org/10.1186/s13023-016-0543-7
Chiam LYT, Verhagen MMM, Haraldsson A, Wulffraat N, Driessen GJ, Netea MG, et al. Cutaneous Granulomas in Ataxia Telangiectasia and Other Primary Immunodeficiencies: Reflection of Inappropriate Immune Regulation? Dermatology. 2011;223(1):13–9. DOI: https://doi.org/10.1159/000330335
Buchbinder D, Hauck F, Albert MH, Rack A, Bakhtiar S, Shcherbina A, et al. Rubella Virus-Associated Cutaneous Granulomatous Disease: a Unique Complication in Immune-Deficient Patients, Not Limited to DNA Repair Disorders. J Clin Immunol. 2019 Jan;39(1):81–9. DOI: https://doi.org/10.1007/s10875-018-0581-0
Neven B, Pérot P, Bruneau J, Pasquet M, Ramirez M, Diana JS, et al. Cutaneous and Visceral Chronic Granulomatous Disease Triggered by a Rubella Virus Vaccine Strain in Children With Primary Immunodeficiencies: Table 1. Clin Infect Dis. 2017 Jan 1;64(1):83–6. DOI: https://doi.org/10.1093/cid/ciw675
Browne R, Cliffe L, Ip W, Brown K, McDermott E. A case of wild‐type rubella‐associated cutaneous granuloma in ataxia telangiectasia. Pediatr Dermatol. 2022 Jul;39(4):619–21. DOI: https://doi.org/10.1111/pde.15032
Groß M, Speckmann C, May A, Gajardo-Carrasco T, Wustrau K, Maier SL, et al. Rubella vaccine–induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity. J Allergy Clin Immunol. 2022 Jan;149(1):388-399.e4. DOI: https://doi.org/10.1016/j.jaci.2021.05.007
Perelygina L, Plotkin S, Russo P, Hautala T, Bonilla F, Ochs HD, et al. Rubella persistence in epidermal keratinocytes and granuloma M2 macrophages in patients with primary immunodeficiencies. J Allergy Clin Immunol. 2016 Nov;138(5):1436-1439.e11. DOI: https://doi.org/10.1016/j.jaci.2016.06.030
Perelygina L, Buchbinder D, Dorsey MJ, Eloit M, Hauck F, Hautala T, et al. Outcomes for Nitazoxanide Treatment in a Case Series of Patients with Primary Immunodeficiencies and Rubella Virus-Associated Granuloma. J Clin Immunol. 2019 Jan;39(1):112–7. DOI: https://doi.org/10.1007/s10875-019-0589-0
Baumann U, Schulte JH, Groß JP, Beier R, Ludwig M, Wahn V, et al. Case Report: Rubella Virus-Induced Cutaneous Granulomas in Two Pediatric Patients With DNA Double Strand Breakage Repair Disorders – Outcome After Hematopoietic Stem Cell Transplantation. Front Immunol. 2022 Jun 2;13:886540. DOI: https://doi.org/10.3389/fimmu.2022.886540
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