Unilateral eosinophilic fasciitis (Shulman syndrome) with excellent response to combined treatment with methotrexate therapy and compression brace


Published: 24 August 2023
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Authors

  • Corrado Zengarini Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria, Bologna; Department of Medical and Surgical Sciences, University of Bologna, Italy.
  • Giacomo Clarizio Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria, Bologna; Department of Medical and Surgical Sciences, University of Bologna, Italy.
  • Federico Bardazzi Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria, Bologna; Department of Medical and Surgical Sciences, University of Bologna, Italy. https://orcid.org/0000-0001-6162-2004
  • Martina Mussi Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria, Bologna; Department of Medical and Surgical Sciences, University of Bologna, Italy.
  • Carlotta Baraldi Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria, Bologna; Department of Medical and Surgical Sciences, University of Bologna, Italy.
  • Bianca Maria Piraccini Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria, Bologna; Department of Medical and Surgical Sciences, University of Bologna, Italy. https://orcid.org/0000-0001-6537-9689
  • Alessandro Pileri Dermatology Unit, IRCCS of Azienda Ospedaliero-Universitaria, Bologna; Department of Medical and Surgical Sciences, University of Bologna, Italy. https://orcid.org/0000-0002-1025-7171

Dear Editor, We report the case of a 78-year-old Caucasian male examined in our dermatological unit for swelling of the right arm. He described an increase in right arm size, which had a slow and progressive growth over the last two years and a perception of skin hardening and difficulty in flexing and extending the joint. Moreover, he has been experiencing muscle pain during the previous eight months. [...]


Lebeaux D, Sène D. Eosinophilic fasciitis (Shulman disease). Best Pract Res Clin Rheumatol 2012;26:449-58.

Long H, Zhang G, Wang L, Lu Q. Eosinophilic skin diseases: a comprehensive review. Clin Rev Allergy Immunol 2016;50:189-213.

Urzal J, Cimbron M, Mendonça T, Farinha F. Eosinophilic fasciitis (Shulman’s disease): review and comparative evaluation of seven patients. Reumatologia 2019;57:85-90.

Primitivo A, Madeira N, Lopez D, Afonso D. Eosinophilic fasciitis (Shulman disease) with clinical, imaging and pathological correlation. BMJ Case Rep 2021;14(:e246151.

Lakhanpal S, Ginsburg WW, Michet CJ, et al. Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases. Semin Arthritis Rheum 1988;17:221-31.

Pehl D, Preuße C, Allenbach Y, et al. Eosinophilic fasciitis (Shulman syndrome)-recognition of the histological spectrum allows for new insights into possible pathomechanisms. Rheumatology (Oxford) 2023;62:2005-14.

Shinozaki A, Hayashi S, Hongo T, et al. Efficacy of methotrexate for steroid-resistant eosinophilic fasciitis with delayed start of treatment: a case report. Int J Dermatol 2023;62:e67-8.

Mikhal’chik EV, Piterskaya JA, Budkevich LY, et al. Comparative study of cytokine content in the plasma and wound exudate from children with severe burns. Bull Exp Biol Med 2009;148:771-5.

Saito M, Shima C, Takagi M, et al. Enhanced exudation of fibrinogen into the perivascular space in acute inflammation triggered by neutrophil migration. Inflamm Res 2002;51:324-31.

Baum SJ, MacVittie TJ, Brandenburg RT, Levin SG. Stimulatory effects of products from inflammatory exudates upon stem cell production. Exp Hematol 1978;6:405-9.

Zengarini, C., Clarizio, G., Bardazzi, F., Mussi, M., Baraldi, C., Piraccini, B. M., & Pileri, A. (2023). Unilateral eosinophilic fasciitis (Shulman syndrome) with excellent response to combined treatment with methotrexate therapy and compression brace. Dermatology Reports, 16(2). https://doi.org/10.4081/dr.2023.9807

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