Flagellate dermatitis in a patient with testicular germ cell neoplasia on bleomycin
https://doi.org/10.4081/dr.2023.9761
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Bleomycin, an antineoplastic antibiotic that inhibits DNA synthesis, is used to treat various malignant tumors such as Hodgkin’s lymphoma, squamous cell carcinoma, and germ cell tumors. Flagellate erythema is a rare rash with a linear pattern that has been observed in association with bleomycin treatment. Herein, we present a 43-year-old patient with metastatic testicular cell neoplasms who developed a whiplash rash during treatment with a chemotherapy regimen that included bleomycin. A typical case of bleomycin-related flagellate dermatitis has been diagnosed and the main features of this characteristic adverse drug event are briefly discussed.
Indrastuti N, Mariyani S, Meidiyanti P. Flagellate dermatitis in bleomycin chemotherapy: a causality? BMJ Case Rep 2022;15:e249704. DOI: https://doi.org/10.1136/bcr-2022-249704
Moulin MMJ, Fière B, Beyvin A. Cutaneous pigmentation caused by bleomycin. Bull Soc Fr Dermatol Syphiligr 1970;293-6.
Turan Erkek E, Karaali CN, Yılmaz G, Gültürk E. Bleomycin-Induced Flagellate Dermatitis. Turk J Haematol 2019;36:138-40. DOI: https://doi.org/10.4274/tjh.galenos.2019.2018.0317
Maruthappu T, Hader Z. A characteristic rash caused by Shiitake mushrooms – An emerging concern?. Clin Case Rep 2021;9:e04181. DOI: https://doi.org/10.1002/ccr3.4181
Rehan HS, Chopra D, Kakkar AK. Physician's guide to pharmacovigilance: terminology and causality assessment. Eur J Intern Med 2009;20:3-8. DOI: https://doi.org/10.1016/j.ejim.2008.04.019
Nayak N, Friedmann PS, Healy E. Case 2. Bleomycin-induced flagellate dermatosis. Clin Exp Dermatol 2003;28:105-6. DOI: https://doi.org/10.1046/j.1365-2230.2003.01114.x
Grynszpan R, Niemeyer-Corbellini JP, Lopes MS, Ramos-e-Silva M. Bleomycin-induced flagellate dermatitis. BMJ Case Rep 2013;2013:bcr20130097647. DOI: https://doi.org/10.1136/bcr-2013-009764
Diao DY, Goodall J. Bleomycin-induced flagellate dermatitis. CMAJ 2012;184:1280. DOI: https://doi.org/10.1503/cmaj.111889
Biswas A, Julka PK. Bleomycin- induced flagellate erythema in a patient with thalamic mixed germ cell tumour: Report of a rare adverse effect. J Egypt Natl Canc Inst 2016;28:129-32. DOI: https://doi.org/10.1016/j.jnci.2016.04.002
Fyfe AJ, McKay P. Toxicities associated with bleomycin. J R Coll Physicians Edinb 2010;40:213-5. DOI: https://doi.org/10.4997/JRCPE.2010.306
Cullingham K, Kost G. A case of bleomycin-induced flagellate dermatitis: A case report. SAGE Open Med Case Rep 2021;9:2050313X211039476. DOI: https://doi.org/10.1177/2050313X211039476
Chen Y-B, Rahemtullah A, Breeden E, Hochberg EP. Bleomycin-induced flagellate erythema. J Clin Oncol 2007;25:898-900. DOI: https://doi.org/10.1200/JCO.2006.09.7691
Adjade G, El Fadli M, Afani L, Belbaraka R. Bleomycin-Induced flagellate erythema in a patient with germ cell tumor. Our Dermatol Online 2020;11:18–20. DOI: https://doi.org/10.7241/ourd.2020S3.6
Le A, Farmakiotis D, Reagan JL. Pruritic rash in a patient with Hodgkin’s lymphoma. Cureus 2018;10:e2450. DOI: https://doi.org/10.7759/cureus.2450
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