Cutaneous squamous cell carcinoma of the lip successfully treated with rhenium-188 brachytherapy


Submitted: 8 July 2022
Accepted: 10 January 2023
Published: 14 June 2023
Abstract Views: 443
PDF: 296
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Authors

Cutaneous squamous cell carcinoma (SCC) is the second most common form of skin cancer. In most cases, non-invasive SCC has a good prognosis and is curable by surgical resection. Nevertheless, a small percentage of patients pose specific management problems due to the technical difficulty of maintaining function and aesthetics because of the size or location of the tumor. An emerging therapeutic approach with high-dose brachytherapy using a nonsealed rhenium-188 resin, commercially known as Rhenium-Skin Cancer Therapy®, has been shown to be highly effective in non-invasive carcinoma, up to a thickness of 2-3 mm.


Que SKT, Zwald FO, Schmults CD. Cutaneous squamous cell carcinoma: incidence, risk factors, diagnosis, and staging. J Am Acad Dermatol 2018;78:237-47.

Dessinioti C, Stratigos AJ. Overview of guideline recommendations for the management of high-risk and advanced cutaneous squamous cell carcinoma. J Eur Acad Dermatol Venereol 2021;36:11-8.

Shimizu I, Cruz A, Chang KH, Dufresne RG. Treatment of squamous cell carcinoma in situ: a review. Dermatol Surg 2011;37:1394-411.

Castellucci P, Savoia F, Farina A, et al. High dose brachytherapy with non sealed 188Re (rhenium) resin in patients with non-melanoma skin cancers (NMSCs): single center preliminary results. Eur J Nucl Med Mol Imaging 2021;48:1511-21.

Stratigos AJ, Garbe C, Dessinioti C, et al. European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: part 1. Epidemiology, diagnostics and prevention. Eur J Cancer 2020;128:60-82.

Farasat S, Yu SS, Neel VA, et al. A new American joint committee on cancer staging system for cutaneous squamous cell carcinoma: creation and rationale for inclusion of tumor (T) characteristics. J Am Acad Dermatol 2011;64:1051-9.

Cipriani C, Desantis M, Dahlhoff G, et al. Personalized irradiation therapy for NMSC by rhenium-188 skin cancer therapy: a long-term retrospective study. J Dermatolog Treat 2020;33:969-75.

Sedda AF, Rossi G, Cipriani C, et al. Dermatological high-dose-rate brachytherapy for the treatment of basal and squamous cell carcinoma. Clin Exp Dermatol 2008;33:745-9.

Carrozzo AM, Sedda AF, Muscardin L, et al. Dermo beta brachytherapy with 188-Re in squamous cell carcinoma of the penis: a new therapy. Eur J Dermatol 2013;23:183-8.

Sabbadini, C., Patta, F., Lorenzon, L., Farsad, M., & Nobile, C. (2023). Cutaneous squamous cell carcinoma of the lip successfully treated with rhenium-188 brachytherapy. Dermatology Reports, 15(3). https://doi.org/10.4081/dr.2023.9560

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