Malignant eccrine spiradenocylindroma and parotid gland involvement in Brooke-Spiegler syndrome


Published: 26 January 2022
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Authors

  • Giulia Merlo Dermatology Unit, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy. https://orcid.org/0000-0003-0767-4684
  • Marianna Pesce Department of Plastic and Reconstructive Surgery, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
  • Tiziana Borra Department of Pathology, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
  • Ileana Orejuela Department of Plastic and Reconstructive Surgery, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
  • Francesca Pasquali Vulnology Unit, Local Health Department of Alessandria, Italy.
  • Renzo Panizza Department of Plastic and Reconstructive Surgery, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
  • Marco Ghiglione Department of Plastic and Reconstructive Surgery, SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.
  • Federica Grosso Translational Medicine, Integrated Activities Research and Innovation Department (DAIRI), SS. Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy.

Brooke-Spiegler syndrome is a rare disorder, characterized by the development of skin adnexal tumors, including cylindromas, trichoepitheliomas, spiradenomas. Although these neoplasms are benign in most patients, a malignant transformation can rarely occur. Furthermore, an occasional association between cutaneous adnexal tumors and basal cell adenoma as well as adenocarcinoma of the parotid gland has been rarely described, with approximately 20 cases reported. We report a case of Brooke-Spiegler syndrome presenting with a malignant eccrine spiradenocylindroma, in a patient with previous history of parotid basal cell tumor.


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Merlo, G. ., Pesce, M. ., Borra, T. ., Orejuela, I. ., Pasquali, F. ., Panizza, R. ., Ghiglione, M. ., & Grosso, F. . (2022). Malignant eccrine spiradenocylindroma and parotid gland involvement in Brooke-Spiegler syndrome. Dermatology Reports, 14(3). https://doi.org/10.4081/dr.2022.9418

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