Signet-ring cells in the skin: a case of late-onset cutaneous metastasis of gastric carcinoma and a brief review of histological approach


Submitted: 4 August 2016
Accepted: 24 November 2016
Published: 4 January 2017
Abstract Views: 1964
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Up to 10% of patients with visceral malignancies develop skin metastases during their clinical course and these metastases constitute about 2% of all skin cancers. Skin metastasis may be the first sign of a clinically silent visceral cancer or represent recurrence of an internal malignancy. In both situations, they are associated with poor prognosis, which can partly be attributed to underdiagnosis. In this paper, a case of relapsing gastric adenocarcinoma, which manifested itself as asymptomatic cutaneous papules and nodules on a patient’s head and neck, is reported and histopathological approach to the cutaneous lesions containing signet-ring cell is briefly reviewed.

Supporting Agencies


Gündüz Özgür, Emeksiz, M. C., Atasoy, P., Kıdır, M., Yalçın, S., & Demirkan, S. (2017). Signet-ring cells in the skin: a case of late-onset cutaneous metastasis of gastric carcinoma and a brief review of histological approach. Dermatology Reports, 8(1). https://doi.org/10.4081/dr.2016.6819

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