Drug-free antibacterial polymers for biomedical applications

  • Ayesha Idrees Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; Clinical Research Center, RUHR University Bochum, Bochum, Germany.
  • Patrícia Varela Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; Clinical Research Center, RUHR University Bochum, Bochum, Germany.
  • Francesca Ruini Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
  • Jeddah Marie Vasquez Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; Vornia Biomaterials Ltd, Dublin, Ireland.
  • Jochen Salber Clinical Research Center, RUHR University Bochum, Bochum; Clinic of Surgery, Knappschaftskrankenhaus Bochum, Hospital of the RUHR University, Bochum, Germany.
  • Udo Greiser Vornia Biomaterials Ltd, Dublin, Ireland.
  • Wenxin Wang Vornia Biomaterials Ltd, Dublin, Ireland.
  • Sean McMahon Vornia Biomaterials Ltd, Dublin, Ireland.
  • Susanna Sartori Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
  • Gianluca Ciardelli Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.
  • Valeria Chiono | valeria.chiono@polito.it Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

Abstract

Microbial colonization on biomaterials is the main cause of failure of a successful implantation. In fact, local infections can eventually evolve in severe sepsis that might finally end up in a multi-organ failure and death of the patient.  Besides, infection has become one of the toughest problems in the medical world, as microorganisms become more resistant to known drugs. Scientific research has been focussing on exploring new strategies to combat this life-threatening problem. In this review, information was collected about currently used polymeric biomaterials in the medical field and the main bacterial infections associated with their implantation. Furthermore, drug-free strategies to overcome this complication are explored, and the existing methodology required for assessment of the antibacterial activity is also described.

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Published
2018-05-10
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Section
Reviews
Keywords:
Biopolymers, Biomedical devices, Implants, Antibacterial polymers, Polymer composites
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How to Cite
Idrees, A., Varela, P., Ruini, F., Vasquez, J. M., Salber, J., Greiser, U., Wang, W., McMahon, S., Sartori, S., Ciardelli, G., & Chiono, V. (2018). Drug-free antibacterial polymers for biomedical applications. Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.2018.39