Versatile electrical stimulator for providing cardiac-like electrical impulses in vitro


https://doi.org/10.4081/bse.111
Vol. 1 No. 1 (2020)
Published: 14 February 2020
Electrical stimulation, cardiac tissue engineering, in vitro models, versatility
Abstract views:
763


PDF:
333
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

  • Stefano Gabetti PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy; Interuniversity Center for the Promotion of the 3Rs Principles in Teaching and Research, Italy, Italy.
  • Giovanni Putame PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
  • Federica Montrone PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
  • Giuseppe Isu Department of Surgery and Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
  • Anna Marsano Department of Surgery and Department of Biomedicine, Basel University Hospital, Basel, Switzerland.
  • Alberto Audenino PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.
  • Diana Massai
    diana.massai@polito.it
    PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin; Interuniversity Center for the promotion of the 3Rs principles in teaching and research, Italy.

In the perspective of reliable methods alternative to in vivo animal testing for cardiac tissue engineering (CTE) research, the versatile electrical stimulator ELETTRA has been developed. ELETTRA delivers controlled and stable cardiac-like electrical impulses, and it can be coupled to already existing bioreactors for providing in vitro combined biomimetic culture conditions. Designed to be cost-effective and easy to use, this device could contribute to the reduction and replacement of in vivo animal experiments in CTE.


Gabetti, S., Putame, G., Montrone, F., Isu, G., Marsano, A., Audenino, A., & Massai, D. (2020). Versatile electrical stimulator for providing cardiac-like electrical impulses in vitro. Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.111

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Most read articles by the same author(s)