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  Optimization of primary hepatocyte isolation for the pharmacological characterization of metabotropic glutamate receptor (mGluR) subtype 5: a study on Reduction

  Clarissa Berardo, Andrea Ferrigno, Veronica Siciliano, Marta Cagna, Plinio Richelmi, Mariapia Vairetti, Laura G. Di Pasqua

  29-09-2021

  Published: 29 September 2021

  280

  PDF: 193
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  Characterising the current provision of education and training courses relevant to the Replacement, Reduction and Refinement (Three Rs) of animals used for scientific purposes

  Adelaide Dura, Marcelle Holloway

  11-02-2020

  Published: 11 February 2020

  867

  PDF: 419
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  The 3Rs: Reduction and refinement through a multivariate statistical analysis approach in a behavioural study to unveil anxiolytic effects of natural extracts of Tilia tomentosa

  Guendalina Olivero, Federica Turrini, Matteo Vergassola, Raffaella Boggia, Paola Zunin, Dario Donno, Gabriele Loris Beccaro, Massimo Grilli, Anna Pittaluga

  14-02-2020

  Published: 14 February 2020

  586

  PDF: 321
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  Bioreactors as physiologicallike in vitro models

  Sara Mantero, Federica Boschetti

  11-02-2020

  Published: 11 February 2020

  349

  PDF: 252
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  Development of a multiscale testing method for the reduction of soft biological tissues waste during mechanical characterization

  Andrea T. Lugas, Gianpaolo Serino, Mara Terzini, Cristina Bignardi, Alberto L. Audenino

  29-09-2021

  Published: 29 September 2021

  657

  PDF: 210
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  The Italian Centro 3R: Mission and early achievements presented during the Second Annual Meeting

  Arti Ahluwalia

  11-02-2020

  Published: 11 February 2020

  422

  PDF: 261
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  Detection of pathogens from environmental samples for the evaluation of the health status of laboratory animals

  Andrea Cacciamali, Chiara Romano, Martina Angela Checco, Riccardo Villa

  29-09-2021

  Published: 29 September 2021

  509

  PDF: 308
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  Health monitoring program for the control of laboratory animal diseases

  Chiara Romano, Andrea Cacciamali, Silvia Dotti, Riccardo Villa

  14-02-2020

  Published: 14 February 2020

  637

  PDF: 297
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  Minimum performance level definition for bone plate testing according to standard: A preliminary study

  Federico A. Bologna, Mara Terzini, Andrea T. Lugas, Alberto L. Audenino

  29-09-2021

  Published: 29 September 2021

  340

  PDF: 267
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  Application of two in vitro methods for the toxicity test of autogenous vaccines

  Erika Molica Colella, Silvia Dotti, Riccardo Villa, Guerino Lombardi, Massimo Amadori

  14-02-2020

  Published: 14 February 2020

  566

  PDF: 274
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  Application of reduction and refinement principles in the evaluation of prodromal markers of Parkinson’s disease in a progressive neurotoxic mouse model using multi-tracer PET imaging

  M. Tassan Mazzocco, S. Belloli, A. Pinna, M. Serra, M. Morelli, R. M. Moresco

  16-11-2023

  Published: 16 November 2023

  184

  PDF: 105
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  Versatile electrical stimulator for providing cardiac-like electrical impulses in vitro

  Stefano Gabetti, Giovanni Putame, Federica Montrone, Giuseppe Isu, Anna Marsano, Alberto Audenino, Diana Massai

  14-02-2020

  Published: 14 February 2020

  771

  PDF: 337
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  Centro 3R: Organ and tissue sharing project

  Manuela Marcoli

  11-02-2020

  Published: 11 February 2020

  301

  PDF: 228
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  Norecopa: A database of global 3R resources for better Science

  Adrian J. Smith

  29-09-2021

  Published: 29 September 2021

  1319

  PDF: 297