https://doi.org/10.4081/bse.82
Reconstituted epithelial corneal tissues for evaluation of drug delivery
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
One possible approach to reduce the use of animals in the evaluation of the ocular drug delivery is that to use cell cultures as model of tissues. In this study are compared two different reconstituted epithelial corneal tissues, a homemade artificial corneal epithelium (Reconstituted Rabbit Corneal Epithelium) and a commercial human corneal epithelial model (COR-100 EpiCornealTM, MatTek), for permeation experiments of three drugs with different physical chemical properties: timolol maleate, cyclosporin A, and a newly synthesized compound, MAGL 17.b. The collected data show that corneal epithelial models are not sufficient to simulate the complexity of the corneal barrier and the presence of a layer simulating the stroma may be necessary to approach the structure of native cornea.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Most read articles by the same author(s)
- Erica Zucchetti, Daniela Monti, Patrizia Chetoni, Silvia Tampucci, Susi Burgalassi, Reconstituted epithelial tissues and native cornea: A comparison of the influence of surfactants on ocular permeability , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
- Erica Zucchetti, Leonardo Ling, Daniela Monti, Patrizia Chetoni, Silvia Tampucci, Susi Burgalassi, Polyvinyl alcohol/cellulose hydrogel as possible corneal stroma substitute in drug permeation tests , Biomedical Science and Engineering: Vol. 2 No. 1 (2021)
Similar Articles
- Erica Zucchetti, Daniela Monti, Patrizia Chetoni, Silvia Tampucci, Susi Burgalassi, Reconstituted epithelial tissues and native cornea: A comparison of the influence of surfactants on ocular permeability , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
- Erica Zucchetti, Leonardo Ling, Daniela Monti, Patrizia Chetoni, Silvia Tampucci, Susi Burgalassi, Polyvinyl alcohol/cellulose hydrogel as possible corneal stroma substitute in drug permeation tests , Biomedical Science and Engineering: Vol. 2 No. 1 (2021)
- Manuela Marcoli, Centro 3R: Organ and tissue sharing project , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
- Alessio Malacrida, Mirko Rivara, Omar Ben Mariem, Alessandro Di Domizio, Giacomo Cislaghi, Mariarosaria Miloso, Valentina Zuliani, Gabriella Nicolini, Innovative 3D proteome-wide scale identification of ALKBH5 target for MV1035 small molecule able to reduce migration and invasiveness in U87 glioblastoma cell lines by SPILLO-PBSS , Biomedical Science and Engineering: Vol. 2 No. 1 (2021)
- Andrea T. Lugas, Gianpaolo Serino, Mara Terzini, Cristina Bignardi, Alberto L. Audenino, Development of a multiscale testing method for the reduction of soft biological tissues waste during mechanical characterization , Biomedical Science and Engineering: Vol. 2 No. 1 (2021)
- Massimiliano Runfola, Michele Perni, Simona Sestito, Grazia Chiellini, Michele Vendruscolo, Simona Rapposelli, SG-2: A promising lipolytic and pro-autophagic hit-compound to treat Alzheimer's disease , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
- Sara Mantero, Federica Boschetti, Bioreactors as physiologicallike in vitro models , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
- Paola Occhetta, Roberta Visone, Stefano Piazza, Ferran Lozano, Marco Rasponi, Beating organs-on-chip as technological platforms in drug screening: advanced in vitro models of human physiology and pathology , Biomedical Science and Engineering: Vol. 3 No. 1 (2022)
- Gianvito Grasso, Lorenzo Pallante, Jack A. Tuszynski, Umberto Morbiducci, Marco A. Deriu, Computational molecular modelling as a platform for a deeper understanding of protein dynamics and rational drug design , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
- Paola Petrini, Daniela Pacheco, Francesco Briatico Vangosa, Cosmin S. Butnarasu, Livia Visai, Orietta Monticelli, Laura Pastorino, Sonja Visentin, Hydrogel-based platforms to mimic in vivo drug diffusion: A multicenter research , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
You may also start an advanced similarity search for this article.
