An osteochondral bio-engineered model to in vitro mimicking osteoarthritis


Published: 29 September 2021
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Authors

  • Giorgia Cerqueni Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Annachiara Scalzone School of Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Xiao Nong Wang Translational and Clinical Research Institute, Newcastle University, Newcastle Upon Tyne, United Kingdom.
  • Caterina Licini Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Kenny Dalgarno School of Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Ana Marina Ferreira-Duarte School of Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Piergiorgio Gentile School of Engineering, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Monica Mattioli Belmonte Department of Clinical and Molecular Sciences, Università Politecnica delle Marche, Ancona, Italy.

To date, treatments of Osteoarthritis are not able to provide the pathology regression. In vitro models are therefore necessary to: i) investigate the mechanisms involved in the disease evolution, ii) identify pharmacological targets, and iii) perform predictive tests for new drug delivery strategies.


Cerqueni, G., Scalzone, A., Wang, X. N., Licini, C., Dalgarno, K., Ferreira-Duarte, A. M. ., Gentile, P., & Belmonte, M. M. (2021). An osteochondral bio-engineered model to <em>in vitro</em> mimicking osteoarthritis . Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.162

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