Superoxide dismutase 1 (SOD1) and cadmium: a three models approach to the comprehension of its neurotoxic effects


Published: 29 September 2021
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Authors

  • Federica Bovio Department of Biotechnology and Biosciences, University of Milano-Bicocca, Italy, Milan, Italy.
  • Barbara Sciandrone Department of Biotechnology and Biosciences, University of Milano- Bicocca, Italy, Milan, Italy.
  • Chiara Urani Department of Earth and Environmental Sciences, University of Milan Bicocca, Milan, Italy; Integrated Models for Prevention and Protection in Environmental and Occupational Health, (MISTRAL), Interuniversity Research Center, Italy.
  • Paola Fusi Department of Biotechnology and Biosciences, University of Milano- Bicocca, Italy, Milan; Integrated Models for Prevention and Protection in Environmental and Occupational Health, (MISTRAL), Interuniversity Research Center, Italy.
  • Matilde Forcella Department of Biotechnology and Biosciences, University of Milano- Bicocca, Italy, Milan, Italy.
  • Maria Elena Regonesi Department of Biotechnology and Biosciences, University of Milano- Bicocca, Italy, Milan; Milan Center of Neuroscience (NeuroMI), Milan, Italy.

In three different biological models, the recombinant protein expressed in E. coli, the neuronal cells SH-SY5Y and the nematode Caenorhabditis elegans, cadmium inhibits SOD1 activity without affecting its expression level.


Bovio, F., Sciandrone, B., Urani, C., Fusi, P., Forcella, M., & Regonesi, M. E. (2021). Superoxide dismutase 1 (SOD1) and cadmium: a three models approach to the comprehension of its neurotoxic effects. Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.157

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