A novel in silico tool for dose assessment in cell culture nanotoxicology


Published: 29 September 2021
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Authors

  • Ermes Botte Research Centre “E. Piaggio”, University of Pisa; Department of Information Engineering, University of Pisa, Italy.
  • Pietro Vagaggini Research Centre “E. Piaggio”, University of Pisa, Italy.
  • Joana Costa Research Centre “E. Piaggio”, University of Pisa, Italy.
  • Lara Faccani Institute of Science and Technology for Ceramics, CNR, Faenza, Italy.
  • Ilaria Zanoni Institute of Science and Technology for Ceramics, CNR, Faenza, Italy.
  • Anna Costa Institute of Science and Technology for Ceramics, CNR, Faenza, Italy.
  • Arti Ahluwalia Research Centre “E. Piaggio”, University of Pisa; Department of Information Engineering, University of Pisa, Italy.

Dose assessment is essential for understanding the mechanisms triggering nanomaterial toxicity in vitro and for meaningful translations to in vivo. We propose a novel computational approach for improving the accuracy of biological dose-response characterization, demonstrating its robustness for insoluble Engineered Nanomaterials (ENMs).


Botte, E., Vagaggini, P., Costa, J., Faccani, L., Zanoni, I., Costa, A., & Ahluwalia, A. (2021). A novel <em>in silico</em> tool for dose assessment in cell culture nanotoxicology. Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.156

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