Rigenera protocol: Elucidation of the mechanisms involved in wound healing


https://doi.org/10.4081/bse.133
Vol. 3 No. 1 (2022)
Published: 28 September 2021
Wound healing, autologous micrografts, skin regeneration, ERK pathway
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Authors

  • Gabriele Ceccarelli
    gabriele.ceccarelli@unipv.it
    Department of Public Health, Experimental Medicine and Forensic, University of Pavia, Pavia; Centre of Health Technologies, University of Pavia, Pavia, Italy; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium, Italy.
  • Martina Balli Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Riccardo Bellazzi Centre of Health Technologies, University of Pavia, Pavia, Italy; Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
  • Maurilio Sampaolesi Department of Public Health, Experimental Medicine and Forensic, University of Pavia, Pavia; Centre of Health Technologies, University of Pavia, Pavia, Italy; Department of Development and Regeneration, Stem Cell Institute, KU Leuven, Leuven, Belgium.
  • Gabriella Cusella Department of Public Health, Experimental Medicine and Forensic, University of Pavia, Pavia; Centre of Health Technologies, University of Pavia, Pavia, Italy.

In this study, we show an approach that follow 3R guidelines in order to demonstrate how Autologous Micrografts (AMG) modulates primary fibroblast migration and accelerates skin re-epithelialization without affecting cell proliferation.


Ceccarelli, G., Balli, M., Bellazzi, R., Sampaolesi, M., & Cusella, G. (2021). Rigenera protocol: Elucidation of the mechanisms involved in wound healing. Biomedical Science and Engineering, 3(1). https://doi.org/10.4081/bse.133

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