https://doi.org/10.4081/bse.123
Reconstituted epithelial tissues and native cornea: A comparison of the influence of surfactants on ocular permeability
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The aim of this study was to prepare an artificial rabbit corneal epithelium (RRCE) to compare with a human corneal epithelial model and excised rabbit cornea through permeation studies to investigate differences of surfactants influence on ocular permeability of a lipophilic compound. First solubility assays with different surfactants were performed and the integrity of the RRCE was assessed by measuring transepithelial electrical resistance (TEER). The permeation parameters showed that the RRCE was more sensitive than native cornea and human cornal epithelial model to the effect of permeation enhancers.
How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Most read articles by the same author(s)
- Susi Burgalassi, Erica Zucchetti, Eleonora Terreni, Daniela Monti, Silvia Tampucci, Patrizia Chetoni, Reconstituted epithelial corneal tissues for evaluation of drug delivery , Biomedical Science and Engineering: Vol. 1 No. 1 (2020)
- Erica Zucchetti, Leonardo Ling, Daniela Monti, Patrizia Chetoni, Silvia Tampucci, Susi Burgalassi, Polyvinyl alcohol/cellulose hydrogel as possible corneal stroma substitute in drug permeation tests , Biomedical Science and Engineering: Vol. 2 No. 1 (2021)
