Hydrogel-based platforms to mimic in vivo drug diffusion: A multicenter research


https://doi.org/10.4081/bse.101
Vol. 1 No. 1 (2020)
Published: 12 February 2020
In vitro models, diffusion profiles, hydrogels, mucins, permeability
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Authors

  • Paola Petrini
    paola.petrini@polimi.it
    Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Milan, Italy.
  • Daniela Pacheco Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Milan, Italy.
  • Francesco Briatico Vangosa Department of Chemistry, Materials and Chemical Engineering "G. Natta", Politecnico di Milano, Milan, Italy.
  • Cosmin S. Butnarasu Molecular Biotechnology and Health Sciences Department, University of Torino, Turin, Italy.
  • Livia Visai Department of Molecular Medicine, Center for Health Technologies (CHT), University of Pavia, Pavia; Department of Occupational Medicine, Toxicology and Environmental Risks, S. Maugeri Foundation, IRCCS, Pavia, Italy.
  • Orietta Monticelli Department of Chemistry and Industrial Chemistry, University of Genoa, Genoa, Italy.
  • Laura Pastorino Department of Informatics, Bioengineering, Robotics and System Engineering, University of Genoa, Genoa, Italy.
  • Sonja Visentin Molecular Biotechnology and Health Sciences Department, University of Torino, Turin, Italy.

An airway mucus model is proposed thus serving as an in vitro screening tool with the aim to reduce the number of noneffective drugs reaching the preclinical trials. The engineered mucus model is an easy-to-use and easy-to-produce tool that can be easily coupled to state-of-art diffusion models and it is compatible with high throughput analysis. This platform will serve as the basis to implement the complexity of the model in terms of components, also including the effect of bacteria


Petrini, P., Pacheco, D., Briatico Vangosa, F., Butnarasu, C. S., Visai, L., Monticelli, O., Pastorino, L., & Visentin, S. (2020). Hydrogel-based platforms to mimic in vivo drug diffusion: A multicenter research. Biomedical Science and Engineering, 1(1). https://doi.org/10.4081/bse.101

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