Is photodynamic therapy with curcumin suitable for combating monkeypox?
https://doi.org/10.4081/idhm.2023.345
Accepted: 13 July 2023
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Monkeypox (MPX) is a zoonotic viral infection caused by the Monkeypox Virus (MPXV), which may spread person-to-person directly. It is currently being treated with previously intended drugs for smallpox or other diseases caused by the orthopoxvirus, such as tecovirimat, cidofovir, and brincidofovir. The smallpox vaccination is also the treatment for MPX, consisting of Immune Globulin (IG) combined with human plasma. However, this type of vaccine may cause several neurological adverse events such as headache, pain, vertigo, dizziness, and non-serious limb paresthesia. Up to the present, there are no available treatments, Antimicrobial Photodynamic Therapy (aPDT) may be a good choice for specifically targeting the MPXV because it is a non-invasive approach without side effects. The strategy is according to the principle of Photodynamic Therapy (PDT) and its photodynamic action of curcumin for the research process on MPX. Why do we apply PDT with "curcumin" as a Photosensitizer (PS) against MPX, and is this a possible choice?
Alakunle EF, Okeke MI. Monkeypox virus: a neglected zoonotic pathogen spreads globally. Nat Rev Microbiol. 2022;20:507-8. DOI: https://doi.org/10.1038/s41579-022-00776-z
Rabaan AA, Abas AH, Tallei TE, et al. Monkeypox outbreak 2022: What we know so far and its potential drug targets and management strategies. J Med Virol. 2023;95:e28306. DOI: https://doi.org/10.1002/jmv.28306
Rizk JG, Lippi G, Henry BM, et al. Prevention and Treatment of Monkeypox. Drugs. 2022;82(9):957-963. Epub 2022 Jun 28. Erratum in: Drugs. 2022;82:1343. DOI: https://doi.org/10.1007/s40265-022-01742-y
Farahat RA, Shrestha AB, Elsayed M, Memish ZA. Monkeypox vaccination: Does it cause neurologic and psychiatric manifestations? - Correspondence. Int J Surg. 2022;106:106926. DOI: https://doi.org/10.1016/j.ijsu.2022.106926
Mitton D, Ackroyd R. A brief overview of photodynamic therapy in Europe. Photodiagnosis Photodyn Ther. 2008;5:103-11. DOI: https://doi.org/10.1016/j.pdpdt.2008.04.004
Correia JH, Rodrigues JA, Pimenta S, et al. Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions. Pharmaceutics. 2021;13:1332. DOI: https://doi.org/10.3390/pharmaceutics13091332
Law S, Lo C, Han J, et al. Photodynamic therapy with curcumin for combating SARS-CoV-2. Photodiagnosis Photodyn Ther. 2021;34:102284. DOI: https://doi.org/10.1016/j.pdpdt.2021.102284
Dai C, Lin J, Li H, et al. The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems. Antioxidants (Basel). 2022;11:459. DOI: https://doi.org/10.3390/antiox11030459
Jennings MR, Parks RJ. Curcumin as an Antiviral Agent. Viruses. 2020;12:1242. DOI: https://doi.org/10.3390/v12111242
Xie L, Ji X, Zhang Q, Wei Y. Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer. Biomed Pharmacother. 2022;146:112567. DOI: https://doi.org/10.1016/j.biopha.2021.112567
Kunnumakkara AB, Hegde M, Parama D, Girisa S, Kumar A, Daimary UD, Garodia P, Yenisetti SC, Oommen OV, Aggarwal BB. Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials. ACS PharmacolTransl Sci. 2023;6:447-518. DOI: https://doi.org/10.1021/acsptsci.2c00012
Pereira AHC, Marcolino LMC, Pinto JG, Ferreira-Strixino J. Evaluation of the Photodynamic Therapy with Curcumin on L. braziliensis and L. major Amastigotes. Antibiotics (Basel). 2021;10:634. DOI: https://doi.org/10.3390/antibiotics10060634
Dahl TA, McGowan WM, Shand MA, Srinivasan VS. Photokilling of bacteria by the natural dye curcumin. Arch Microbiol. 1989;151:183-5. DOI: https://doi.org/10.1007/BF00414437
Mitjà O, Ogoina D, Titanji BK,et al. Monkeypox. Lancet. 2023;401:60-74. Erratum in: Lancet. 2022;400:1926. DOI: https://doi.org/10.1016/S0140-6736(22)02075-X
Santezi C, Reina BD, Dovigo LN. Curcumin-mediated Photodynamic Therapy for the treatment of oral infections-A review. Photodiagnosis Photodyn Ther. 2018;21:409-15. DOI: https://doi.org/10.1016/j.pdpdt.2018.01.016
Kashef N, Huang YY, Hamblin MR. Advances in antimicrobial photodynamic inactivation at the nanoscale. Nanophotonics. 2017;6:853-79. DOI: https://doi.org/10.1515/nanoph-2016-0189
Dovigo LN, Pavarina AC, Carmello JC, et al. Susceptibility of clinical isolates of Candida to photodynamic effects of curcumin. Lasers Surg Med. 2011;43:927-34. DOI: https://doi.org/10.1002/lsm.21110
Dovigo LN, Carmello JC, de Souza Costa CA, et al. Curcumin-mediated photodynamic inactivation of Candida albicans in a murine model of oral candidiasis. Med Mycol. 2013;51:243-51. DOI: https://doi.org/10.3109/13693786.2012.714081
Paschoal MA, Tonon CC, Spolidório DM, et al. Photodynamic potential of curcumin and blue LED against Streptococcus mutans in a planktonic culture. Photodiagnosis Photodyn Ther. 2013;10:313-9. DOI: https://doi.org/10.1016/j.pdpdt.2013.02.002
Lee HJ, Kang SM, Jeong SH, et al. Antibacterial photodynamic therapy with curcumin and Curcuma xanthorrhiza extract against Streptococcus mutans. Photodiagnosis Photodyn Ther. 2017;20:116-9. DOI: https://doi.org/10.1016/j.pdpdt.2017.09.003
Ferrisse TM, Dias LM, de Oliveira AB, et al. Efficacy of curcumin-mediated antibacterial photodynamic therapy for oral antisepsis: A systematic review and network meta-analysis of randomized clinical trials. Photodiagnosis Photodyn Ther. 2022;39:102876. DOI: https://doi.org/10.1016/j.pdpdt.2022.102876
Leite DP, Paolillo FR, Parmesano TN, et al. Effects of photodynamic therapy with blue light and curcumin as mouth rinse for oral disinfection: a randomized controlled trial. Photomed Laser Surg. 2014;32:627-32. DOI: https://doi.org/10.1089/pho.2014.3805
Randazzo W, Aznar R, Sánchez G. Curcumin-Mediated Photodynamic Inactivation of Norovirus Surrogates. Food Environ Virol. 2016;8:244-50. DOI: https://doi.org/10.1007/s12560-016-9255-3
Zupin L, Fontana F, Clemente L, et al. Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a Photosensitizer. Viruses. 2022;14:2132. DOI: https://doi.org/10.3390/v14102132
Pourhajibagher M, Bahador A. Virtual screening and computational simulation analysis of antimicrobial photodynamic therapy using propolis-benzofuran A to control of Monkeypox. Photodiagnosis Photodyn Ther. 2023;41:103208. DOI: https://doi.org/10.1016/j.pdpdt.2022.103208
Wang YJ, Pan MH, Cheng AL, et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J. Pharm. Biomed. Anal.1997;15:1867-76. DOI: https://doi.org/10.1016/S0731-7085(96)02024-9
Liu Y, Zhang C, Pan H, et al. An insight into the in vivo imaging potential of curcumin analogues as fluorescence probes. Asian J Pharm Sci. 2021;16:419-431. DOI: https://doi.org/10.1016/j.ajps.2020.11.003
Niu T, Tian Y, Cai Q, et al. Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin. PLoS One. 2015;10:e0138754. DOI: https://doi.org/10.1371/journal.pone.0138754
Zhang P, Han T, Xia H, et al. Advances in Photodynamic Therapy Based on Nanotechnology and Its Application in Skin Cancer. Front Oncol. 2022;12:836397. DOI: https://doi.org/10.3389/fonc.2022.836397
Pourhajibagher M, RanjbarOmrani L, Noroozian M, et al. In vitro antibacterial activity and durability of a nano-curcumin-containing pulp capping agent combined with antimicrobial photodynamic therapy. Photodiagnosis Photodyn Ther. 2021;33:102150. DOI: https://doi.org/10.1016/j.pdpdt.2020.102150
Bonfim CMD, Monteleoni LF, Calmon MF, et al. Antiviral activity of curcumin-nanoemulsion associated with photodynamic therapy in vulvar cell lines transducing different variants of HPV-16. Artif Cells Nanomed Biotechnol. 2020;48:515-24. DOI: https://doi.org/10.1080/21691401.2020.1725023
Liu ZY, Tang XY, Huang CQ, et al. 808 nm NIR-triggered Camellia sapogein/curcumin-based antibacterial upconversion nanoparticles for synergistic photodynamic-chemical combined therapy. Inorg. Chem. Front. 2022;9:1836-46. DOI: https://doi.org/10.1039/D1QI01569A
Aspiroz C, Sevil M, Toyas C, Gilaberte Y. Photodynamic Therapy With Methylene Blue for Skin Ulcers Infected With Pseudomonas aeruginosa and Fusarium spp. Actas Dermosifiliogr. 2017;108:e45-8. DOI: https://doi.org/10.1016/j.adengl.2017.05.010
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