“Lemongrass” and its applications for the treatment of hypertension


Submitted: 6 November 2021
Accepted: 9 December 2021
Published: 20 December 2021
Abstract Views: 2472
PDF: 577
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Hypertension (high blood pressure) is the pre-symptom of cardiovascular disease. The number of people living with hypertension has doubled to 1.28 billion and proportionally increased until today. This is a long-term disease and requires continuous monitoring. A traditional Chinese herbal, “Lemongrass”, might be a good choice for the mainstay of hypertension. Some library search engines are used, such as SCI/SCIE, PubMed, and Scopus, within ten to twenty years, from 1999-2020. The searched keywords and phrases are “lemongrass”, “formulation”, “traditional Chinese medicine”, “hydrogel”, “hypertension”, “lemongrass + tea formulation”, “lemongrass + hydrogel”, “Lemongrass + Hypertension”, “Lemongrass + traditional Chinese medicine” etc. This minireview discusses the background of hypertension, lemongrass, research progress, mechanism, lemongrass tea formulations, lemongrass with Traditional Chinese Medicine (TCM) formulations, and the lemongrass hydrogel application in the treatment of hypertension.


Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol 2020;16:223-37. DOI: https://doi.org/10.1038/s41581-019-0244-2

Singh S, Shankar R, Singh GP. Prevalence and associated risk factors of hypertension: A cross-sectional study in urban Varanasi. Int J Hypertens 2017;2017:5491838. DOI: https://doi.org/10.1155/2017/5491838

Olowofela AO, Isah AO. A profile of adverse effects of antihypertensive medicines in a tertiary care clinic in Nigeria. Ann Afr Med 2017;16:114-9. DOI: https://doi.org/10.4103/aam.aam_6_17

Ekpenyong CE, Akpan E, Nyoh A. Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus (DC) Stapf extracts. Chin J Nat Med 2015;13:321-37. DOI: https://doi.org/10.1016/S1875-5364(15)30023-6

Devi RC, Sim SM, Ismail R. Effect of Cymbopogon citratus and Citral on vascular smooth muscle of the isolated thoracic rat aorta. Evid Based Complement Alternat Med 2012;2012:539475. DOI: https://doi.org/10.1155/2012/539475

Dzeufiet PD, Mogueo A, Bilanda DC, et al. Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model. BMC Complement Altern Med 2014;14:507. DOI: https://doi.org/10.1186/1472-6882-14-507

Nambiar VS, Matela H. Potential Functions of Lemon Grass (Cymbopogon citratus) in Health and Disease. Int J Pharm 2012;3:1035-43.

Somparn N, Saenthaweeuk S, Naowaboot J, et al. Effect of lemongrass water extract supplementation on atherogenic index and antioxidant status in rats. Acta Pharm 2018;68:185-97. DOI: https://doi.org/10.2478/acph-2018-0015

Ekpenyong CE. Lemongrass tea consumption and changes in Acid-Base Balance and Electrolyte homeostasis. Arch Food Nutr Sci 2018;2:41-51. DOI: https://doi.org/10.29328/journal.afns.1001016

Rhiouani H, Settaf A, Lyoussi B, et al. Effects of sap on ins. from Hemiaria glabra on blood pressure and renal function in spontaneously hypertensive rats. Therapie 1999;54:735-9.

Jouad H, Haloui M, Rhiouani H, et al. Ethnobotanical survey of medicinal plants used for the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez–Boulemane). J Ethnopharmacol 2001;77:175-82. DOI: https://doi.org/10.1016/S0378-8741(01)00289-6

Chen M, Long Z, Wang Y, et al. Protective effects of saponin on a hypertension target organ in spontaneously hypertensive rats. Exp Ther Med 2013;5:429-32. DOI: https://doi.org/10.3892/etm.2012.856

Ullah N, Nazir A, Anwar S, et al. Effect of Lemongrass and green tea on blood pressure and heart rate. Medical Forum Mon 2011;22:11-3.

Koner S, Dash P, Priya V, Rajeswari VD. Natural and artificial beverages: Exploring the pros and cons. Natural Beverages 2019;13:427-45. DOI: https://doi.org/10.1016/B978-0-12-816689-5.00015-8

Mirghani MES, Liyana Y, Parveen J. Bioactivity analysis of lemongrass (Cymbopogan citratus) essential oil. Int Food Res J 2012;19:569-75.

Ekpenyong CE, Daniel NE, Antai AB. Effect of lemongrass tea consumption on estimated glomerular filtration rate and creatinine clearance rate. J Ren Nutr 2015;1:57-66. DOI: https://doi.org/10.1053/j.jrn.2014.08.005

Lee MS, Lee J, Park BJ, Miyazaki Y. Interaction with indoor plants may reduce psychological and physiological stress by suppressing autonomic nervous system activity in young adults: a randomized crossover study. J Physiol Anthropol 2015;34:21. DOI: https://doi.org/10.1186/s40101-015-0060-8

De Matos SP, Teixeira HF, De Lima ÁAN, Veiga-Junior VF, Koester LS. Essential Oils and Isolated Terpenes in Nanosystems Designed for Topical Administration: A Review. Biomolecules 2019;9:138. DOI: https://doi.org/10.3390/biom9040138

Campos J, Schmeda-Hirschmann G, Leiva E, et al. Lemongrass (Cymbopogon citratus (D.C) Stapf) polyphenols protect human umbilical vein endothelial cell (HUVECs) from oxidative damage induced by high glucose, hydrogen peroxide and oxidised low-density lipoprotein. Food Chem 2014;151:175-81. DOI: https://doi.org/10.1016/j.foodchem.2013.11.018

Chiriac AP, Rusu AG, Nita LE, et al. Polymeric carriers designed for encapsulation of essential oils with biological activity. Pharmaceutics 2021;13:631. DOI: https://doi.org/10.3390/pharmaceutics13050631

Law, S., & Lo, C. (2021). “Lemongrass” and its applications for the treatment of hypertension. Infectious Diseases and Herbal Medicine, 2(1). https://doi.org/10.4081/idhm.2021.172

Downloads

Download data is not yet available.

Citations