Could Scutellaria barbata D. Don be used for treating lung cancer and SARS-CoV-2?


Submitted: 14 September 2021
Accepted: 27 October 2021
Published: 10 November 2021
Abstract Views: 414
PDF: 168
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Authors

  • Siukan Law Department of Science, School of Science and Technology, Hong Kong Metropolitan University, Ho Man Tin, Kowloon, Hong Kong, China.
  • Albert Wingnang Leung School of Nursing, Tung Wah College, Ho Man Tin, Kowloon, Hong Kong, China.
  • Chuanshan Xu Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Dear Editor,

Scutellaria barbata D. Don (SBD) is a perennial herb and belongs to the “Lamiaceae” family. This is widely used in China for a long time as Traditional Chinese Medicine (TCM). Based on the TCM theory, SBD is in the category of “Heat-Clearing”. Its functions are to remove heat and detoxification, disperse blood stasis and diuresis. [...]


Puri BK, White N, Monro JA. The effect of supplementation with Scutellaria baicalensis on hepatic function. Med Hypotheses 2019;133:109402. DOI: https://doi.org/10.1016/j.mehy.2019.109402

Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49. DOI: https://doi.org/10.3322/caac.21660

Liu HL, Kao TH, Shiau CY, Chen BH. Functional components in Scutellaria barbata D. Don with anti-inflammatory activity on RAW 264.7 cells. J Food Drug Anal 2018;26:31-40. DOI: https://doi.org/10.1016/j.jfda.2016.11.022

Yin X, Zhou J, Jie C, et al. Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sci 2004;75:2233-44. DOI: https://doi.org/10.1016/j.lfs.2004.05.015

Chen CC, Kao CP, Chiu MM, Wang SH. The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells. Oncotarget 2017;8:109340-57. DOI: https://doi.org/10.18632/oncotarget.22677

Gong T, Wang CF, Yuan JR, et al. Inhibition of tumor growth and immunomodulatory effects of flavonoids and Scutebarbatines of Scutellaria barbata D. Don in Lewis-Bearing C57BL/6 Mice. Evid Based Complementary Altern Med 2015;2015:630760. DOI: https://doi.org/10.1155/2015/630760

Tsai HH. Composition for preventing cancer and treating cancer and intensifying the effects of other anticancer drugs. US Patent 2014: US9789153B2.

Wang Q, Acharya N, Liu Z, et al. Enhanced anticancer effects of Scutellaria barbata D. Don in combination with traditional Chinese medicine components on non-small cell lung cancer cells. J Ethnopharmacol 2018;217:140-51. DOI: https://doi.org/10.1016/j.jep.2018.02.020

Hoffmann M, Kleine-Weber H, Schroeder S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020;181:271-80. DOI: https://doi.org/10.1016/j.cell.2020.02.052

Huang ST, Chen Y, Chang WC, et al. Scutellaria barbata D. Don inhibits the main proteases (Mpro and TMPRSS2) of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) Infection. Viruses 2021;13:826. DOI: https://doi.org/10.3390/v13050826

Law, S., Leung, A. W., & Xu, C. (2021). Could <em>Scutellaria barbata</em> D. Don be used for treating lung cancer and SARS-CoV-2?. Infectious Diseases and Herbal Medicine, 2(1). https://doi.org/10.4081/idhm.2021.163

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