Infection status of hydatid cysts in Iran: A review
Accepted: 11 May 2021
Appendix: 105
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Cystic echinococcosis (CE) is a significant zoonosis, and is endemic in some parts of the world including Iran. Hydatid cyst in Iran has been studied from different aspects and has been reported from most parts of the country. But there is no comprehensive report on the appearance of pollution in the country. This study was conducted to investigate the approximate status of infection from 1985 to 2019. In this review article, various reports on hydatid cysts were collected from 1985 to 2019. According to three criteria, i.e. the rate of infection of dogs with adult worms, the rate of infection of livestock, and the rate of infection of humans with hydatid cysts, the articles were summarized and presented to approximate the status of infection in Iran. In this study, the average infection among 11593 dogs was estimated to be 11.28%. In the case of livestock, according to this review, the maximum infection of sheep was in Ardebil with 74.4%, goats and cattle were in Sari with 37.8% and 40.1%, camels in Khorasan Razavi with 40.40%, and Tabriz had the highest amount of infection in buffaloes. Out of 70907 people tested, the summary of seroepidemiological studies shows that the average infection in humans is 5.57%. The information obtained from this review article shows that despite the efforts of health organizations and veterinary organizations, the rate of infection in Iran is still high compared to some countries.
Darani HY, Avijgan M, Karimi K, et al. Seroepidemiology of hydatid cyst in Chaharmahal va Bakhtiari Province, Iran. Iranian J Public Health 2003:31-3.
Moro P, Schantz PM. Echinococcosis: a review. Int J Infect Dis 2009;13:125-33.
Sadjjadi SM. Present situation of echinococcosis in the Middle East and Arabic North Africa. Parasitol Int 2006;55:S197-S202.
Arti H, Darani HY. Fibular hydatid cyst. Indian J Orthopaed 2007;41:244.
Yousofi Darani H, Hashemzadeh-Chaleshtori M, Aliyari Z, et al. Molecular characterization of the strains cause sheep-Hydatid cyst, in Chaharmahal va Bakhtiary province using restriction fragment length polymorphism. J Shahrekord Univ Med Sci 2007;9.
Saeed I, Kapel C, Saida L, et al. Epidemiology of Echinococcus granulosus in Arbil province, northern Iraq, 1990–1998. J Helminthol 2000;74:83-8.
Shafiei R, Teshnizi SH, Kalantar K, et al. The seroprevalence of human cystic echinococcosis in Iran: a systematic review and meta-analysis study. J Parasitol Res 2016;2016.
Khalkhali H, Foroutan M, Khademvatan S, et al. Prevalence of cystic echinococcosis in Iran: a systematic review and meta-analysis. J Helminthol 2018;92:260-8.
Rafiei A, Panabad E, Beiromvand M. The seroprevalence of cystic echinococcosis in a rural normal population, southwestern Iran. Infect Disorders-Drug Targets 2019;19:113-7.
Yousefi H. A review of the status of hydatid cyst infection in Iran in the years 1364-1384. J Shahrekord Univ Sci 2008;10:78-88.
Chai J. Epidemiological studies on cystic echinococcosis in China--a review. Biomedical and environmental sciences: BES 1995;8:122.
Buishi I, Walters T, Guildea Z, et al. Reemergence of canine Echinococcus granulosus infection, Wales. Emerging Infect Dis 2005;11:568.
Buishi I, Njoroge EM, Bouamra O, Craig PS. Canine echinococcosis in northwest Libya: assessment of coproantigen ELISA, and a survey of infection with analysis of risk-factors. Veterinary Parasitol 2005;130:223-32.
Garippa G, Varcasia A, Scala A. Cystic echinococcosis in Italy from the 1950s to present. Parassitologia 2004;46:387-91.
Pandey V, Ouhelli H, Moumen A. Epidemiology of hydatidosis/echinococcosis in Ouarzazate, the pre-Saharian region of Morocco. Ann Tropical Med Parasitol 1988;82:461-70.
Moosa RA, Abdel-Hafez SK. Serodiagnosis and seroepidemiology of human unilocular hydatidosis in Jordan. Parasitol Res 1994;80:664-71.
Bai Y, Cheng N, Wang Q, Cao D. An epidemiological survey of cystic echinococcosis among Tibetan school pupils in West China. Ann Tropical Paediatr 2001;21:235-8.
El-Shazly A, Saad RM, Belal US, Sakr T, Zakae HA. Evaluation of ELISA and IHAT in serological diagnosis of proven cases of human hydatidosis. J Egypt Soc Parasitol 2010;40:531-8.
Maleky F, Moradkhan M. Echinococcosis in the stray dogs of Tehran, Iran. Ann Tropical Med Parasitol 2000;94:329-31.
Y H. A review of the status of hydatid cyst infection in Iran in 2005-2006. J Shahrekord Univ Sci 2008;10:78-88.
Eslami A, Hosseini SH. Echinococcus granulosus infection of farm dogs of Iran. Parasitol Res 1998;84:205-7.
Parviz M, Akbar AMA, Pourmohammad A. Study of infection of stray dogs with Echinococcus granulosus in Tabriz. Med J Tabriz Univ Med Sci 1989;30:57-67.
Dalimi A, Motamedi G, Hosseini M, et al. Echinococcosis/hydatidosis in western Iran. Vet Parasitol 2002;105:161-71.
Da AH. Prevalence of Echinococcus granulosus infection in stray dogs in the province Mazandaran in 1989. Scientific Information Center (virtual) 2001;1:80-90.
Motakef M, Minou A, Lari M. An epidemiological approach to the study of echinococcosis in North-East region of Iran (Khorassan). Pahlavi Med J 1976;7:503-15.
Gholami S, Daryani A, Sharif M, et al. A comparison of the prevalence of Echinococcosis Granulosus in stray dogs in Sari city, in 1991 and 2007. J Mazandaran Univ Med Sci 2011;20:70-5.
Razmi GR, Sardari K, Kamrani A. Prevalence of Echinococcus granulosus and other intestinal helminths of stray dogs in Mashhad area, Iran. Arch Razi Institute Fall 2006;61:143-8.
Shariatzadeh SA, Spotin A, Gholami S, et al. The first morphometric and phylogenetic perspective on molecular epidemiology of Echinococcus granulosus sensu lato in stray dogs in a hyperendemic Middle East focus, northwestern Iran. Parasites Vectors 2015;8:409.
Beiromvand M, Akhlaghi L, Massom SHF, et al. Prevalence of zoonotic intestinal parasites in domestic and stray dogs in a rural area of Iran. Prev Vet Med 2013;109:162-7.
Dalimi A, Sattari A, Motamedi G. A study on intestinal helminthes of dogs, foxes and jackals in the western part of Iran. Vet Parasitol 2006;142:129-33.
Eslami A, Ranjbar-Bahadori S, Meshgi B, et al. Helminth infections of stray dogs from Garmsar, Semnan province, Central Iran. Iranian J Parasitol 2010;5:37.
Jahangir A, Taherikalani M, Asadolahi K, Emaneini M. Echinococcosis/hydatidosis in Ilam province, western Iran. Iranian J Parasitol 2013;8:417.
Emamapour SR, Borji H, Nagibi A. An epidemiological survey on intestinal helminths of stray dogs in Mashhad, North-east of Iran. J Parasitic Dis 2015;39:266-71.
Mohaghegh M, Vafaei M, Ghomashlooyan M, et al. A wide diversity of zoonotic intestinal parasites in domestic and stray dogs in rural areas of Kermanshah province, Iran. Tropical Biomed 2018;35:82-90.
Adinezadeh A, Eshrat Beigom K, Mohebali M, et al. Endoparasites of stray dogs in Mashhad, Khorasan Razavi province, Northeast Iran with special reference to zoonotic parasites. Iranian J Parasitol 2013;8:459.
Sardarian K, Maghsood A, Ghiasian S, Zahirnia A. Prevalence of zoonotic intestinal parasites in household and stray dogs in rural areas of Hamadan, Western Iran. Trop Biomed 2015;32:240-6.
Ghabdian S, Borji H, Naghibi A. Molecular identification of Echinococcus granulosus strain in stray dogs from northeastern Iran. Vet Parasitol Regional Studies Reports 2017;9:6-8.
Beiromvand M, Rafiei A, Razmjou E, Maraghi S. Multiple zoonotic helminth infections in domestic dogs in a rural area of Khuzestan Province in Iran. BMC Vet Res 2018;14:224.
Yagoob G, Mashaei SS. Prevalence of gastrointestinal helminthic infestation in pet and stray dogs in Tabriz (East-Azerbaijan Province), Iran. J Animal Vet Adv 2011;10:1477-9.
Amouei A, Jahandar H, Daryani A, et al. Carnivores as important reservoirs of intestinal helminthic infections in Mazandaran Province, Northern Iran. Iranian J Parasitol 2018;13:251.
Pestechian N, Rasouli A, Yoosefi HA. Distribution of intestinal worms among stray dogs in Isfahan, Iran. J Isfahan Med School 2012;29.
Abdi J, Asadolahi K, Maleki MH, Ashrafi Hafez A. Prevalence of helminthes infection of stray dogs in Ilam province. J Paramed Sci 2013;4:58-61.
Eslahi AV, Eshrat Beigom K, Mobedi I, et al. Road killed carnivores illustrate the status of zoonotic helminthes in Caspian Sea littoral of Iran. Iranian J Parasitol 2017;12:230.
Keyhani A, Sharifi I, Bamorovat M, et al. Epidemiological and molecular studies on Echinococcus granulosus from free-roaming dogs in Southeast Iran. Vet World 2019;13:739.
Shamsi M, Dalimi A, Khosravi A, Pourahmad F. Determination and Sequencing of Genotypes of Echinococcus granulosus from Stray Dogs isolates with Cox1 Gen in Ilam, West of Iran. Sci J Ilam Univ Med Sci 2017;24:97-106.
Mobedi I, Zare-Bidaki M, Siavashi M, et al. Differential detection of Echinococcus spp. copro-DNA by nested-PCR in domestic and wild definitive hosts in Moghan Plain, Iran. Iranian J Parasitol 2013;8:107.
Keywanloo M, Hashemi Tabar G, Razmi G. Evaluation of Echinococcus granulosus coproantigens by Dot-blotting in dogs. Iranian J Vet Res 2009;10:166-71.
Hejazi S, Pestehchian N, Abdi J. A study of stray dog cestodes in Isfahan. J Isfahan Med School 2004;22:50-53.
Arbabi M, Hooshyar H. Survey of Echinococcosis and Hydatidosis in Kashan Region, Central Iran. Iran J Public Health 2006;35:75-81.
Beiromvand M, Akhlaghi L, Massom SHF, et al. Detection of Echinococcus multilocularis in carnivores in Razavi Khorasan province, Iran using mitochondrial DNA. PLoS Negl Trop Dis 2011;5:e1379.
Kohansal MH, Fazaeli A, Nourian A, et al. Dogs’ gastrointestinal parasites and their association with public health in Iran. J Vet Res 2017;61:189-95.
Elham M, Hassan B, Ghasem NA, et al. Epidemiological study of hydatidosis in the dromedaries (Camelus dromedarius) of different regions of Iran. Asian Pacific J Trop Biomed 2014;4:S148-51.
Azami M, Anvarinejad M, Ezatpour B, Alirezaei M. Prevalence of hydatidosis in slaughtered animals in Iran. Turkiye Parazitol Derg 2013;37:102-6.
Akhlaghi L, Massoud J, Housaini A. Observation on hydatid cyst infection in Kordestan Province (West of Iran) using epidemiological and seroepidemiological criteria. Iranian J Public Health 2005:73-5.
Mirzaei M, Rezaei H, Nematollahi A. Role of ruminants in the epidemiology of Echinococcus granulosus in Tabriz area, Northwest of Iran. Trop Biomed 2015;32:269-75.
Mansoorlakooraj H, Saadati D, Javadi R, et al. A survey on hydatidosis in livestock in Northern Iran based on data collected from slaughterhouses from 2004 to 2008. Vet Parasitol 2011;182:364-7.
Nejad MR, Jahani-Sherafat S, Cheraghipour K, et al. Hydatic cyst prevalence in slaughtered animals, A neglected health problem. Arch Adv Biosci 2012;3.
Rahmani K, Radfar MH, Adinehbeigi K. Hydatidosis: prevalence and biometrical studies in sheep in Kerman area, southeast of Iran. Comparative Clin Pathol 2013;22:723-8.
Oryan A, Goorgipour S, Moazeni M, Shirian S. Abattoir prevalence, organ distribution, public health and economic importance of major metacestodes in sheep, goats and cattle in Fars, southern Iran. Tropical Biomed 2012;29:349-59.
Daryani A, Alaei R, Arab R, et al. The prevalence, intensity and viability of hydatid cysts in slaughtered animals in the Ardabil province of Northwest Iran. J Helminthol 2007;81:13-7.
Youssefi MR, Tabaripour R, Omrani VF, et al. Genotypic characterization of Echinococcus granulosus in Iranian goats. Asian Pacific J Trop Dis 2013;3:362-6.
Elahi J, Moghadam, Ghulamali. Seroepidemiological study of hydatidosis in northwestern Iran using indirect immunofluorescence method. Vet Clin Pathol (Tabriz Veterinary) 2011:1:35-9.
Dabaghzadeh H, Bairami A, Eshrat Beigom K, et al. Seroprevalence of human cystic echinococcosis in Alborz Province, central Iran in 2015. Iranian J Public Health 2018;47:561.
Zibaei M, Azargoon A, Ataie-Khorasgani M, et al. The serological study of cystic echinococcosis and assessment of surgical cases during 5 years (2007-2011) in Khorram Abad, Iran. Nigerian J Clin Pract 2013;16:221-5.
Asghari M, Mohebali M, Eshrat Beigom K, et al. Seroepidemiology of human hydatidosis using AgB-ELISA test in Arak, central Iran. Iranian J Public Health 2013;42:391.
Moshfe A, Sarkari B, Arefkhah N, et al. Seroepidemiological study of cystic echinococcosis in nomadic communities in the southwest of Iran: a population-based study. J Immunoassay Immunochem 2019;40:183-92.
Sarkari B, Hosseini F, Khabisi SA, Sedaghat F. Seroprevalence of cystic echinococcosis in blood donors in Fars province, southern Iran. Parasite Epidemiol Control 2017;2:8-12.
Tavalla M, Akhlaghi L, Ourmazdi H, et al. Using Dot-ELISA method to study the prevalence of human hydatidosis in people referred to blood transfusion center in Tehran, 2005-2006. Razi J Med Sci 2010;16:52-8.
Mirzanejad-Asl H, Ghoreishi M, Ghahramani A, Mehmandar W. Serological and sonographical survey of hydatid disease in Moghan Plain of Iran. Res J Med Sci 2010;4:75-80.
Baharsefat M, Massoud J, Mobedi I, et al. Seroepidemiology of human hydatidosis in Golestan province, Iran. Iranian J Parasitol 2007:20-4.
Omrani VF, Rouhani S, Kazemi B, Seyyedtabaei SJ, Kheirandish F, Rezapour M. Seroprevalence of IgG antibodies against echinococcus granulosus by ELISA method using recombinant agb in Lorestan province, Western Iran. Iranian J Public Health 2017;46:1132.
Esmaeili N, Arbabi M. Seroepidemiology of hydatidosis among adult human at Kashan region, Iran in 2008. KAUMS Journal (FEYZ) 2010;13:321-6.
Rakhshanpour A, Harandi MF, Moazezi S, et al. Seroprevalence of human hydatidosis using ELISA method in Qom province, central Iran. Iranian J Parasitol 2012;7:10.
Sarkari B, Sadjjadi S, Beheshtian M, et al. Human cystic Echinococcosis in Yasuj district in Southwest of Iran: an epidemiological study of seroprevalence and surgical cases over a ten‐year period. Zoonoses Public Health 2010;57:146-50.
Heidari Z, Mohebali M, Zarei Z, et al. Seroepidemiological study of human hydatidosis in Meshkinshahr district, Ardabil province, Iran. Iranian J Parasitol 2011;6:19.
Fathi S, Ghasemikhah R, Mohammadi R, et al. Seroprevalence of Hydatidosis in People Referring to Reference Laboratory of Gorgan, Golestan Province, Northern Iran 2017. Iranian J Parasitol 2019;14:436.
Harandi M, Moazezi S, Saba M, et al. Sonographical and serological survey of human cystic echinococcosis and analysis of risk factors associated with seroconversion in rural communities of Kerman, Iran. Zoonoses Public Health 2011;58:582-8.
Sharafi AC, Kheirandish F, Valipour M, et al. Seroepidemiology of human cystic echinococcosis among nomads of Lorestan province, Iran. Arch Clin Infect Dis 2018;13.
Youssefi MR, Mirshafiei S, Moshfegh Z, et al. Cystic echinococcosis is an occupational disease? J Parasitic Dis 2016;40:586-90.
Moghadam MB, Hajilooi M, Fallah M, et al. Seroprevalence of hydatidosis in outpatients attending health centers in Hamadan City, 2017. Clin Med 2018;25:99-104.
Esmaali Ghouraneh M, Saberi M, Farhadineko S, et al. Seroepidemiological study of hydatid cyst using AgB by ELISA in patients admitted to central laboratory of Baqiyatallah Hospital. Int J Enteric Pathog 2019;7:15-8.
Moradi H, Maroufi Y, Dabirzadeh M. Seroepidemiology of human hydatid cyst in Shahrebabk using ELISA. J Mazandaran Univ Med Sci 2016;25:315-8.
Hadadian M, Ghaffarifar F, Dalimi Asl A, Roudbar Mohammadi S. Seroepidemiological survey of hydatid cyst by ELISA in Kordestan province. Pathobiol Res 2008;10:13-8.
Manouchehri-Naeini K, Jaffari M, Kheiri S, eds. Sero-Prevalence and Risk Factors of Human Hydatidosis in Chaharmahal VA Bakhtiyari Province, South West of Iran using ELISA Method, 2014-2015. Proceeding of 2th International and 9th National Iranian Congress of Parasitology and Parasitic Diseases Guilan, Iran (Abstract); 2015: p. 235.
Sadjjadi S, Noormohammadi A, Mohammadzadeh T, Fata A, eds. Seroepidemiological study of hydatid cyst using AgB ELISA in Torbat-Jaam, Khorasan Razavi Province, Iran. Proceeding of 2th International and 9th National Iranian Congress of Parasitology and Parasitic Diseases Guilan, Iran (Abstract); 2015: p. 228.
Shahrokhabadi R, Rahimi E, Poursahebi R. Seroepidemiological study of human hydatidosis in Rafsanjan, Kerman. Zahedan J Res Med Sci 2014;16:46.
Dadkhah MA, Yeganehzad M, Nadery B. Survey on Hydatid Cyst infestation in Sarab city (Northwest of Iran) using epidemiological and seroepidemiological criteria. J Animal Vet Adv 2011;10:2099-101.
GHaredagi Y, Bahavarniya S. Seroepidemiological study of hydatid cyst by ELISA method in East-Azarbaijan Province (2009). J Kerman Univ Med Sci 2011;18:172-81.
Kavous S, Kazemi A, Jelodari S. Seroepidemiology of human hydatid cyst in jahrom. J Jahrom Univ Med Sci 2010;8:18-24.
Mirzanejad-Asl H. Seroepidemiological survey of human cystic echinococcosis with ELISA method in Moghan plain, Ardabil province. J Ardabil Univ Med Sci 2009;9:334-46.
Moazezi S, Saba M, Kamyabi H, SHikhzadeh F. Sonographic and serological survey of hydatid disease in Rural regions of Shahdad and Chatroud, Kerman province, 2006-2007. J Kerman Univ Med Sci 2009;15:25-34.
Rafiei A, Hemadi A, Maraghi S, et al. Human cystic echinococcosis in nomads of south-west Islamic Republic of Iran. EMHJ-Eastern Mediterranean Health J 2007;13:41-8.
Amiri Z, Massoud J, Sohrabi N, Kia E, editors. Seroepidemiological survey of human hydatid cyst in the city population of Kermanshah Province. Proceedings of national congress on hydatid cyst, Yasuj, Iran (Abstract) Armaghane Danesh J Yasuj Univ Med Sci; 2007.
Gholami S, Tanzifi A, Sharif M, et al. Demographic aspects of human hydatidosis in Iranian general population based on serology: A systematic review and meta-analysis. Vet World 2018;11:1385.
Farokhzad B, Nazaripouya M, Gachkar L, Mosafa N. Seroepidemiologic survey of hydatid cyst in rural area of Shemiranat and determining the efficacy of IFA test. Pajouhesh Dar Pezeshki Journal 2006;30:241-243
Aflaki A, Ghaffarifar F. Dalimi Asl A. Seroepidemiological survey of hydatidosis by Dot-ELISA in Ilam province. J Med Sci Modarres 2005;8:1-6.
Hanilou A, Badali H, Esmaeilzadeh A. Seroepidemiological study of hydatidosis in Zanjan (Islam-Abad 2002). J Adv Med Biomed Res 2004;12:41-6.
Yousefi H, Karimi K, Avijgan M. Seroepidemiology of Hydatid cyst in Chaharmahal and Bakhtiari province, Iran, 2000. J Shahrekord Univ Med Sci 2001;3.
Sedaghatghohar H, Masoud J, Rokni M. Seroepidemiologic study of human Hydatidosis in Shahriar Area: south of Tehran in 1999. J Kerman Univ Med Sci 2001;7:44-9.
Hosseini S, Masoud J, eds. Seroepidemiological study of hydatidosis in Divandarreh, Kurdistan and Sannandaj. Proceeding of the 3rd National Congress of Parasitology and Parasitic Disease in Iran Sari, Mazandaran, Iran; 2001.
Zariffard M, Abshar N, Akhavizadegan M, Motamedi G. Seroepidemiological survey of human hydatidosis in western parts of Iran. Arch Razi Institute 1999;50:71-5.
Arbabi M, Masoud J, Dalimi Asl A, Sajadi M. Seroepidemiologic prevalence of Hydatid cyst in Hamadan 1991. KAUMS Journal (FEYZ) 1998;2:43-50.
Saberi-Firouzi M, Kaffashian F, Hayati E, et al. Prevalence of hydatidosis in nomadic tribes of southern Iran. Med J The Islamic Republic of Iran (MJIRI) 1998;12:113-8.
Davoodi L, Kordi S, Azordeh M, Bahadori A, Bahrami F, Tabarestani M, et al. Seroprevalence of human hydatidosis and survey of risk factors in rural areas of Qaemshahr, Iran 2019. J Mazandaran Univ Med Sci 2020;30:139-45.
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