Radiological evaluation with Computed Tomography in the diagnosis of Medication-Related Osteonecrosis of the Jaw (MRONJ): RAD-ONJ observational study. A preliminary report of the study population


https://doi.org/10.4081/wpph.2023.9786
Vol. 11 (2023)
Submitted: 29 June 2023
Accepted: 6 September 2023
Published: 26 January 2024
bisphosphonates, denosumab, osteonecrosis of jaw, MRONJ, Computed Tomography
Abstract Views: 148
PDF: 69
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Authors

  • Antonella Fasciolo SC Chirurgia Maxillofacciale, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Riccardo Campora SC Radiologia, Azienda Sanitaria Alessandria-Tortona-Novi Ligure, Alessandria, Italy.
  • Vittorio Fusco SC Oncologia, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria; SSD Medicina Traslazionale – Dipartimento Attività Integrate Ricerca Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Costanza Massarino
    costanza.massarino@ospedale.al.it
    SSD Laboratori di Ricerca – Dipartimento Attività Integrate Ricerca Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Francesca Marengo SC Infrastruttura Ricerca Formazione Innovazione – Dipartimento Attività Integrate Ricerca Innovazione, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Giorgia Rossetti SC Oncologia, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. https://orcid.org/0009-0009-5750-7201
  • Paola Brigo Day Hospital Oncoematologico, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Ivan Gallesio SC Radiologia, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Luca Benzi SC Radiologia, Azienda Sanitaria Alessandria, Casale Monferrato, Italy.
  • Maura Rossi SC Oncologia, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. https://orcid.org/0000-0001-9445-0376
  • Federico Monaco SCDU Ematologia, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. https://orcid.org/0000-0002-4630-753X
  • Marco Ladetto SCDU Ematologia, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Antonio Maconi Dipartimento Attività Integrate Ricerca Innovazione, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Background and Aims: Osteonecrosis of the Jaw (ONJ), recently renamed Medication-Related Osteonecrosis of the Jaw (MRONJ), is a recently recognized disease (2003), characterized by alterations including clinical signs and symptoms (not limited to bone exposure) together with jawbone radiological destruction, better assessed by Computed Tomography (CT) scan. We designed an observational (retrospective and prospective) study to systematically investigate the rate of occurrence of the various radiological signs of CT semeiotics, predefined in an appropriate table (i.e., focal and diffuse osteosclerosis, sequestrum, cortical disruption, periosteal reaction, osteolysis, etc.) in patients with MRONJ, diagnosed according to the criteria of the Italian SICMF-SIPMO recommendations (2020). Results: since March 2022, 120 patients with MRONJ were examined; 5 were considered not eligible due to lack of adequate CT images. Clinical data and radiological features of 115 patients were recorded and are under examination. Conclusions: the sample was higher than expected, and it appears sufficient to proceed to the evaluation of radiological features and draw conclusions about the investigated issue.


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Fasciolo, A., Campora, R., Fusco, V., Massarino, C., Marengo, F., Rossetti, G., Brigo, P., Gallesio, I., Benzi, L., Rossi, M., Monaco, F., Ladetto, M., & Maconi, A. (2024). Radiological evaluation with Computed Tomography in the diagnosis of Medication-Related Osteonecrosis of the Jaw (MRONJ): RAD-ONJ observational study. A preliminary report of the study population. Working Paper of Public Health, 11(1). https://doi.org/10.4081/wpph.2023.9786

Copyright (c) 2024 Antonella Fasciolo, Riccardo Campora, Vittorio Fusco, Costanza Massarino, Francesca Marengo, Giorgia Rossetti, Paola Brigo, Ivan Gallesio, Luca Benzi, Maura Rossi, Federico Monaco, Marco Ladetto, Antonio Maconi

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