Post-Covid-19 Syndrome: symptoms and stratified follow-up. A systematic review and meta-analysis


https://doi.org/10.4081/wpph.2022.9540
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Authors

  • Roberta Di Matteo SC Research Training Innovation Infrastructure, Department of Research and Innovation, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Tatiana Bolgeo
    tbolgeo@ospedale.al.it
    SC Research Training Innovation Infrastructure, Department of Research and Innovation, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Denise Gatti SC Research Training Innovation Infrastructure, Department of Research and Innovation, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Menada Gardalini SC Research Training Innovation Infrastructure, Department of Research and Innovation, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Antonella Cassinari SC Research Training Innovation Infrastructure, Department of Research and Innovation, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Antonio Maconi SC Research Training Innovation Infrastructure, Department of Research and Innovation, Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.

Background: Post-COVID-19 syndrome has been found in patients admitted to a hospital with severe conditions of COVID-19 and in adults who initially presented a mild illness. The aim is to underline the available literature on post-COVID-19 follow-up until 12 months about symptoms reported by adults infected with Sars-Cov-2 from at least 12 weeks after disease onset.

Methods: The bibliographic search was conducted on PubMed, Embase, CINHAL, Scopus and the Cochrane Central Register of Controlled Studies.

Results: We found that 68% of patients had at least one symptom post-COVID-19 after 12 weeks and up to 24 weeks post-onset. The most frequent symptoms were fatigue and muscle weakness (26%), dizziness and mental clouding (15%) and taste disturbances (10%).

Conclusions: Health policy needs to prepare for a long-term management plan to address COVID-19, as there are significant needs beyond recovery from the acute infection.