Osteonecrosis of jaw (onj): impact of italian patients, and role of italian physicians, dentists, and researchers in the growing evidence of a “new” disease


Submitted: 18 July 2016
Accepted: 18 July 2016
Published: 15 June 2012
Abstract Views: 599
PDF: 724
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Authors

  • V. Fusco Unit of Oncology, Department of Oncology and Haematology, Italy.
  • A. Baraldi Unit of Haematology, Department of Oncology and Haematology, Italy.
  • A. Fasciolo Unit of Maxillo-Facial Surgery, Italy.
  • M. Rapetti Centro Documentazione e Prevenzione Osteonecrosi, Azienda Ospedaliera di Alessandria (City Hospital), Alessandria, Italy.
  • I. De Martino Unit of Maxillo-Facial Surgery, Italy.
  • L. Randi Unit of Maxillo-Facial Surgery, Italy.
  • A. Bedogni Section of Oral and Maxillofacial Surgery, Department of Surgery, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
  • A. Agrillo Section of Maxillofacial Surgery, Department of Odontostomatologic Sciences, University "La Sapienza", Rome, Italy.
  • G. Campisi Sector of Oral Medicine “V.Margiotta”, Department of Surgical and Oncological Sciences, University of Palermo, Palermo, Italy.
Purpose: Osteonecrosis of jaw (ONJ) is an uncommon but severe complication observed mostly in patients treated with bisphosphonates (BPs) for bone metastases, myeloma, osteoporosis (so called BRONJ, Bisphosphonate-Related Osteonecrosis of Jaw), but also with other drugs (bevacizumab, sunitinib, denosumab). The number of cases observed in Italy appears high in comparison with other countries and we present a review of several aspects of ONJ in Italy and the role of Italian health professionals and researchers on increasing knowledge and adequate reporting of ONJ phenomenon; Methods: Literature review about osteonecrosis of jaw (ONJ) with selection of Italian authors and publications, on year 2003-2011, by research on international electronic journal databases, Italian language journals, congress acta, web sources; Results: at October 2011, among 1272 papers published worldwide on ONJ issue, 128 (10%) were from Italian Authors; Conclusions: relevant articles by Italian groups were published about pathogenesis hypotheses, animal models, biology studies, risk factors, preventive measures, dental extraction protocols in BP-exposed patients, laser therapy, ozone therapy, surgical treatment. Experience of Italian patients suffering from ONJ, together with work of Italian dentists, physicians and researchers, appears of paramount importance in order to study ONJ and minimize a possible severe side-effect of efficacious medical treatments.

Supporting Agencies


Fusco, V., Baraldi, A., Fasciolo, A., Rapetti, M., De Martino, I., Randi, L., Bedogni, A., Agrillo, A., & Campisi, G. (2012). Osteonecrosis of jaw (onj): impact of italian patients, and role of italian physicians, dentists, and researchers in the growing evidence of a “new” disease. Working Paper of Public Health, 1(1). https://doi.org/10.4081/wpph.2012.6778

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