Giant cell tumour of bone: a case report


Submitted: 11 July 2016
Accepted: 11 July 2016
Published: 15 June 2015
Abstract Views: 611
PDF: 4434
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Authors

  • F. Grosso Unità Funzionale Interaziendale Mesotelioma – S.C. Oncologia ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • S. Crivellari S.S.A. S.P.S. – Clinical Trial Center ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • N.F. Trincheri S.O.C. Anatomia Patologica ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • F. Ugo S.S.A. S.P.S. – Clinical Trial Center ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • M.G. Candeo S.S.D. Day Hospital Onco-Ematologico ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • A. Pertino S.C. Oncologia ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • S. Zai Unità Funzionale Interaziendale Mesotelioma – S.C. Oncologia ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • A. Aurelio S.C. Radiologia ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • N. Mariani S.O.C. Anatomia Patologica ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.
  • M. Mancuso S.C. Chirurgia Toracica ASO SS Antonio e Biagio e C. Arrigo, Alessandria, Italy.

Aims/Methodology: We present the story of a patient who was 47 years old at the time of the onset of the disease, with a histological diagnosis of giant cell tumour of the bone (distal radius) and with evidence of pulmonary parenchymal lesions. The patient's clinical situation was such that amputation of the affected limb was considered. Instead, the patient underwent surgical resection with removal of the distal radius, reconstruction and, after tumour recurrence, prolonged treatment with denosumab (a total of 44 administrations, still in progress). Results/Conclusions: Treatment of the recurrence with denosumab resulted in an excellent disease response with clinical benefit, remarkable functional recovery, and with disease stability at the level of the lung lesions.


Grosso, F., Crivellari, S., Trincheri, N., Ugo, F., Candeo, M., Pertino, A., Zai, S., Aurelio, A., Mariani, N., & Mancuso, M. (2015). Giant cell tumour of bone: a case report. Working Paper of Public Health, 4(1). https://doi.org/10.4081/wpph.2015.6705

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