The impact of high-fat diet-induced oxidative stress on micro RNA’s in various tissues
https://doi.org/10.4081/pcr.2023.9529
Accepted: 25 August 2022
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Stress is the body’s reaction to any kind of injury or danger. It is linked to the production of oxidative free radicals, which are responsible for a variety of acute, chronic, and potentially fatal illnesses and diseases. Free radicals, due to their extreme reactivity, can harm or even kill cells. A High-Fat Diet (HFD) causes “oxidative stress”, which is characterized by an increase in the body’s generation of Reactive Oxygen Species (ROS) as a result of higher levels of triglycerides and Free Fatty Acids (FFA). HFD-induced oxidative stress alters cellular function by affecting transcriptional factors and mitochondrial enzymes (synthesis/inhibition). ROS and FFA damage the receptors of the epithelium, resulting in epithelial damage that impairs cellular function. ROS levels can harm cells by altering the expression of microRNA (miRNA), a sign of RNA damage. MiRNAs are non-coding RNAs found in animals, plants, and some viruses that play a role in the post-transcriptional regulation of gene expression. These three pathways—RNA cleavage, RNA destabilization, and RNA translation into proteins— all play a role in mRNA expression. The miRNA regulates the up- and downregulation of mRNA expression for cellular function, enzyme synthesis, and receptor modulation. MiRNA regulates cell function by maintaining the balance between cellular ROS levels and cellular damage.
Kresge N, Simoni RD, Hill RL. The ATP Requirement for fatty acid oxidation: the early work of Albert L. Lehninger. J Biol Chem 2005;280:e11–e12. DOI: https://doi.org/10.1016/S0021-9258(19)60522-3
Trindade de Paula M, Poetini Silva MR, Machado Araujo S, et al. High-fat diet induces oxidative stress and MPK2 and HSP83 gene expression in drosophila melanogaster. Oxid Med Cell Longev 2016;2016:4018157. DOI: https://doi.org/10.1155/2016/4018157
Wahid F, Shehzad A, Khan T, Kim YY. MicroRNAs: Synthesis, mechanism, function, and recent clinical trials. Biochim Biophys Acta - Mol Cell Res 2010;1803:1231–43. DOI: https://doi.org/10.1016/j.bbamcr.2010.06.013
Kesh SB, Sarkar D, Manna K. High-fat diet-induced oxidative stress and its impact on metabolic syndrome: A review. Asian J Pharm Clin Res 2016;9:38–43.
Le Lay S, Simard G, Martinez MC, Andriantsitohaina R. Oxidative stress and metabolic pathologies: From an adipocentric point of view. Oxid Med Cell Longev 2014;2014:908539. DOI: https://doi.org/10.1155/2014/908539
Kim YJ, Hwang SH, Cho HH, et al. MicroRNA 21 regulates the proliferation of human adipose tissue-derived mesenchymal stem cells and high-fat diet-induced obesity alters microRNA 21 expression in white adipose tissues. J Cell Physiol 2012;227:183–93. DOI: https://doi.org/10.1002/jcp.22716
Gharanei S, Shabir K, Brown JE, et al. Regulatory microRNAs in brown, brite and white adipose tissue. Cells 2020;9:2489. DOI: https://doi.org/10.3390/cells9112489
Goto T, Lee JY, Teraminami A, et al. Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. J Lipid Res 2011;52:873–84. DOI: https://doi.org/10.1194/jlr.M011320
Zhao Y, Xiang L, Liu Y, et al. Atherosclerosis induced by a high-cholesterol and high-fat diet in the inbred strain of the wuzhishan miniature pig. Anim Biotechnol 2018;29:110-8. DOI: https://doi.org/10.1080/10495398.2017.1322974
Yu D, Chen G, Pan M, et al. High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4α and leads to hepatic steatosis in mice. J Cell Physiol 2018;233:4770–82. DOI: https://doi.org/10.1002/jcp.26270
Wilson RA, Deasy W, Hayes A, Cooke MB. High fat diet and associated changes in the expression of micro-RNAs in tissue: Lessons learned from animal studies. Mol Nutr Food Res 2017;61. DOI: https://doi.org/10.1002/mnfr.201600943
Berglund L. Lipid biochemistry: An introduction. Am J Clin Nutr 2003;78:353-4. DOI: https://doi.org/10.1093/ajcn/78.2.353a
Craft S, Baker LD, Montine TJ, et al. Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: A pilot clinical trial. Arch Neurol 2012;69:29–38. DOI: https://doi.org/10.1001/archneurol.2011.233
Ilkun O, Boudina S. Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies. Curr Pharm Des 2013;19:4806–17. DOI: https://doi.org/10.2174/1381612811319270003
Zhu J, Chen T, Yang L, et al. Regulation of MicroRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10. PLoS One 2012;7:46551. DOI: https://doi.org/10.1371/journal.pone.0046551
Schimanski CC, Frerichs K, Rahman F, et al. High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. World J Gastroenterol 2009;15:2089–2096. DOI: https://doi.org/10.3748/wjg.15.2089
Arany I, Hall S, Reed DK, et al. Nicotine enhances high-fat diet-induced oxidative stress in the kidney. Nicotine Tob Res 2016;18:1628–34. DOI: https://doi.org/10.1093/ntr/ntw029
Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 1996;97:2859–65. DOI: https://doi.org/10.1172/JCI118742
La Favor JD, Anderson EJ, Hickner RC, Wingard CJ. Erectile dysfunction precedes coronary artery endothelial dysfunction in rats fed a high-fat, high-sucrose, western pattern diet. J Sex Med 2013;10:694–703. DOI: https://doi.org/10.1111/jsm.12001
Schulz MD, Atay Ç, Heringer J, et al. High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity. Nature 2014;514:508–512. DOI: https://doi.org/10.1038/nature13398
Freeman LR, Haley-Zitlin V, Rosenberger DS, Granholm AC. Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms. Nutr Neurosci 2014;17:241–51. DOI: https://doi.org/10.1179/1476830513Y.0000000092
Kuwabara Y, Horie T, Baba O, et al. MicroRNA-451 exacerbates lipotoxicity in cardiac myocytes and high-fat diet-induced cardiac hypertrophy in mice through suppression of the LKB1/AMPK pathway. Circ Res 2015;116:279–88. DOI: https://doi.org/10.1161/CIRCRESAHA.116.304707
Ahn J, Lee H, Jung CH, Ha T. Lycopene inhibits hepatic steatosis via microRNA-21-induced downregulation of fatty acid-binding protein 7 in mice fed a high-fat diet. Mol Nutr Food Res 2012;56:1665–74. DOI: https://doi.org/10.1002/mnfr.201200182
Barbery CE, Celigoj FA, Turner SD, et al. Alterations in microRNA expression in a murine model of diet-induced vasculogenic erectile dysfunction. J Sex Med 2015;12:621–30. DOI: https://doi.org/10.1111/jsm.12793
Takanabe R, Ono K, Abe Y, et al. Up-regulated expression of microRNA-143 in association with obesity in adipose tissue of mice fed high-fat diet. Biochem Biophys Res Commun 2008;376:728–32. DOI: https://doi.org/10.1016/j.bbrc.2008.09.050
Chartoumpekis DV, Zaravinos A, Ziros PG, et al. Differential expression of microRNAs in adipose tissue after long-term high-fat diet-induced obesity in mice. PLoS One 2012;7:34872. DOI: https://doi.org/10.1371/journal.pone.0034872
Copyright (c) 2023 The Authors
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
