https://doi.org/10.4081/jnai.2011.2236

MicroRNAs, SNPs and Cancer

Vol. 2 No. 1 (2011)
Submitted: 23 December 2010
Accepted: 21 March 2011
Published: 11 April 2011
Abstract Views: 4279
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Authors

Angela V. Vitale
Emory University, .
Huiping Tan
Peng Jin
peng.jin@emory.edu
MiRNAs are probable regulators of cell events such as differentiation, propagation and apoptosis. These cellular phenomena are also associated with benign and malignant tumor cells, therefore, it is presumed that miRNAs act as natural oncogenes or tumor suppressor genes. Whether a particular miRNA serves as either could almost be moot when the additional problems of SNPs enter the fray. A miRNA involved with SNPs (miR-SNPs) on any regulatory level, whether naturally cancerinducing or not, could easily undergo an oncogenic transformation. This work reviews targets of miRNAs and the miRNAs themselves frequently containing SNPs reflecting different risks and markers of cancer with emphasis on familial groups and populations of shared heredity.

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How to Cite

Vitale, A. V., Tan, H., & Jin, P. (2011). MicroRNAs, SNPs and Cancer. Journal of Nucleic Acids Investigation, 2(1), e6. https://doi.org/10.4081/jnai.2011.2236

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