https://doi.org/10.4081/jnai.2010.1659

Role of microRNAs in the molecular diagnosis of cancer

Vol. 1 No. 1 (2010)
Submitted: 1 February 2010
Accepted: 8 March 2010
Published: 10 May 2010
Classifier, microRNA, diagnostic tools
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Authors

Simona Giglio
University of Rome La Sapienza, Italy.
Andrea Vecchione
andrea.vecchione@uniroma1.it
University of Rome LA sapienza, Italy.
MicroRNAs (miRNAs) are evolutionarily conserved, endogenous, small non-coding RNA molecules of about 22 nucleotides in length that function as posttranscriptional gene regulators. They are involved in numerous cellular processes including development, cell differentiation, cell cycle regulation and apoptosis. There is increasing evidence to show that miRNAs are mutated or differentially expressed in many types of cancer and specific functions of the miRNAs are now becoming apparent. Here we discuss the current literature on potential usefulness of miRNAs as diagnostic markers, emphasizing the involvement of specific miRNAs in particular tumor types, highlighting their potential role in distinguishing benign from malignant tissues and/or the different subtypes of the same tumor and/or in diagnosis and classification of tumor of unknown origin.

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How to Cite

Giglio, S., & Vecchione, A. (2010). Role of microRNAs in the molecular diagnosis of cancer. Journal of Nucleic Acids Investigation, 1(1), e4. https://doi.org/10.4081/jnai.2010.1659

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