https://doi.org/10.4081/jnai.2130

MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer

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Submitted: 23 October 2010
Accepted: 1 December 2010
Published: 13 December 2010
Micro RNA, Cancer, Biomarker, Chronic Lymphocytic Leukemia
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Authors

Daniela Asslaber
a.egle@salk.at
Laboratory for Immunological and Molecular Cancer Research, University Hospital, Salzburg, Austria.
Josefina Piñón Hofbauer
Richard Greil
Alexander Egle
miRNAs are small-noncoding RNA molecules that regulate gene expression on a posttranscriptional level. A number of oncogenes and tumor suppressors were found to be targets of miRNAs and global miRNA expression signatures were able to distinguish between cancerous and non-cancerous tissues. Therefore it was not surprising that some miRNAs could be linked to the pathogenesis of cancer. In this review we provide an overview of the use of microRNAs as diagnostic and prognostic tools in cancer and focus on the use of miRNA expression as biomarker for disease activity.

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Supporting Agencies

This work was supported by Austrian FWF grants P19481 and L488 to A.E., Austrian National Bank grant 10990 to A.E., and by the state of Salzburg and the SFB 021 to R.G.
Daniela Asslaber, Laboratory for Immunological and Molecular Cancer Research, University Hospital, Salzburg
not applicable

How to Cite

Asslaber, D., Piñón Hofbauer, J., Greil, R., & Egle, A. (2010). MicroRNAs as biomarkers for the diagnosis and prognosis of human cancer. Journal of Nucleic Acids Investigation. https://doi.org/10.4081/jnai.2130
Copyright (c) 2010 Daniela Asslaber, Josefina Piñón Hofbauer, Richard Greil, Alexander Egle Creative Commons License

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