https://doi.org/10.4081/jnai.1625

Induced pluripotent stem cells: the long-expected revolution in medical science and practice?

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Submitted: 14 January 2010
Accepted: 4 February 2010
Published: 1 March 2010
Stem cells, Molecular Medicine, Hematology, Oncology,
Abstract Views: 1235
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Authors

Antonio Sorrentino
antonio.sorrentino@iss.it
Dept. Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Within the matter of a few years, development of the somatic reprogramming technology to generate induced pluripotent stem (iPS) cells has contributed enormously to the stem cell research field. We learned that differentiated adult cells possess an unrestricted plasticity that allows them to be driven back to their embryonic or pluripotent state, but owing to the juvenile nature of this novel science chapter, there are many unanswered questions and dilemmas. It is indisputable, however, that iPS cells potentially could represent the jack-of-all-trades remedy in areas of medicine ranging from toxicology screening to regenerative medicine. In this review I will summarize the current strategies employed to reprogram somatic cells and the major promises and hurdles for the future of iPS cells.

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How to Cite

Sorrentino, A. (2010). Induced pluripotent stem cells: the long-expected revolution in medical science and practice?. Journal of Nucleic Acids Investigation. https://doi.org/10.4081/jnai.1625
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