Disseminated superficial actinic porokeratosis in an elderly patient undergoing androgen deprivation therapy for advanced prostate cancer: exploring the potential association
Accepted: 12 November 2023
HTML: 3
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Porokeratosis is a group of chronic dermatoses characterized by the presence of cornoid lamellae. Disseminated superficial actinic porokeratosis (DSAP) is a common subtype, presenting as multiple small annular scaly lesions primarily in sun-exposed areas. While previous studies have documented DSAP in prostate cancer patients, the association with androgen deprivation therapy (ADT) has not been reported. In this report, we describe an elderly patient with advanced prostate cancer, who developed DSAP subsequent to undergoing ADT. We present the clinical, dermoscopic, and histopathological evaluations, and discuss the potential role of ADT in the pathogenesis of DSAP.
Vargas-Mora P, Morgado-Carrasco D, Fustà-Novell X. Porokeratosis: A review of its pathophysiology, clinical manifestations, diagnosis, and treatment. Actas Dermosifiliogr. 2020;111(7):545–60. DOI: https://doi.org/10.1016/j.adengl.2020.08.005
Tan LS, Chong WS. Porokeratosis in Singapore: an Asian perspective. Australas J Dermatol. 2012;53(2):40–4. DOI: https://doi.org/10.1111/j.1440-0960.2011.00856.x
Hsueh YT, Hsu TC, Hsu CK, Lee J, Yang CC. Disseminated superficial porokeratosis and disseminated superficial actinic porokeratosis: A case series of 39 patients. Dermatologica Sin. 2020;38(4):221–4. DOI: https://doi.org/10.4103/ds.ds_41_20
O’Donnell BP, Dawson NA, Weiss RB. Suramin-induced skin reactions. Arch Dermatol. 1992;128(1):75. DOI: https://doi.org/10.1001/archderm.1992.01680110085011
Teo MY, Rathkopf DE, Kantoff P. Treatment of advanced prostate cancer. Annu Rev Med. 2019;70(1):479–99. DOI: https://doi.org/10.1146/annurev-med-051517-011947
Itoi-Ochi S, Tanemura A, Arase N, Fujimoto M. A case of giant porokeratosis coexisting disseminated superficial porokeratosis. J Cutan Immunol Allergy. 2020;3(6):139–41. DOI: https://doi.org/10.1002/cia2.12141
Batchelor JM, Fife K, Burrows NP. Localized porokeratosis secondary to ionizing radiotherapy for prostate carcinoma. Arch Dermatol. 2010;146(11). DOI: https://doi.org/10.1001/archdermatol.2010.334
Shah PR, Richardson CT, Scott G, Tausk F. Radiation-induced genital porokeratosis and basal cell carcinoma. J Clin Urol. 2018;11(6):440–1. DOI: https://doi.org/10.1177/2051415818754579
Chua IY, Lee J, Chiam L. Pruritic papules on the nose in a 25-year-old female. Indian J Dermatol. 2014;59(1):106. DOI: https://doi.org/10.4103/0019-5154.123553
Zhang S-Q, Jiang T, Li M, et al. Exome sequencing identifies MVK mutations in disseminated superficial actinic porokeratosis. Nat Genet. 2012;44(10):1156–60. DOI: https://doi.org/10.1038/ng.2409
Atzmony L, Choate KA. Second-hit somatic mutations in mevalonate pathway genes underlie porokeratosis. J Invest Dermatol. 2019;139(12):2409–11. DOI: https://doi.org/10.1016/j.jid.2019.07.723
Kumtornrut C, Yamauchi T, Koike S, et al. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts. J Dermatol Sci. 2019;93(3):150–8. DOI: https://doi.org/10.1016/j.jdermsci.2019.01.007
Zaar O, Polesie S, Navarrete‐Dechent C, et al. Dermoscopy of porokeratosis: results from a multicentre study of the International Dermoscopy Society. J Eur Acad Dermatol Venereol. 2021;35(10):2091–6. DOI: https://doi.org/10.1111/jdv.17439
Waqar MU, Cohen PR, Fratila S. Disseminated superficial actinic porokeratosis (DSAP): A case report highlighting the clinical, dermatoscopic, and pathology features of the condition. Cureus. 2022;14(7):e26923. DOI: https://doi.org/10.7759/cureus.26923
Joshi R, Mesquita L. Interface dermatitis without cornoid lamellae is a pitfall in the diagnosis of porokeratosis: A report of three cases. Indian J Dermatol Venereol Leprol. 2016;82(1):70. DOI: https://doi.org/10.4103/0378-6323.162347
Santa Lucia G, Snyder A, Lateef A, et al. Safety and efficacy of topical lovastatin plus cholesterol cream vs topical lovastatin cream alone for the treatment of disseminated superficial actinic porokeratosis. JAMA Dermatol. 2023;159(5):488–95. DOI: https://doi.org/10.1001/jamadermatol.2023.0205
Novice T, Nakamura M, Helfrich Y. The malignancy potential of porokeratosis: single-center retrospective study. Cureus. 2021;13(2):e13083. DOI: https://doi.org/10.7759/cureus.13083
Copyright (c) 2024 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.