Generalized keratosis pilaris induced by testosterone injections in a patient with CHARGE syndrome


Published: 21 April 2023
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Keratosis pilaris (KP) is a common disorder of follicular keratinization characterized by keratotic follicular papules with varying degrees of perifollicular erythema. Keratosis pilaris affects up to half of normal children and up to three-quarters of children with atopic dermatitis. KP is prominent during adolescence and less common in older people, but it may occur in children and adults of all ages. In this report, we describe the case of a 13-year-old boy known to have CHARGE syndrome who developed generalized keratosis pilaris after testosterone injections. To the best of our knowledge, this is the first reported case of generalized keratosis pilaris induced by testosterone injection.


- Hwang S, Schwartz RA. Keratosis pilaris: a common follicular hyperkeratosis. Cutis. 2008 Sep;82(3):177-80.

Pennycook KB, McCready TA. Keratosis Pilaris. 2021 Jul 2- 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–

- Agharbi FZ. Kératose pilaire [Keratosis pilaris]. Pan Afr Med J. 2019 Jul 30;33:274. French. doi: 10.11604/pamj.2019.33.274.16158 DOI: https://doi.org/10.11604/pamj.2019.33.274.16158

- Hsu P, Ma A, Wilson M, Williams G, Curotta J, Munns CF, Mehr S. CHARGE syndrome: a review. J Paediatr Child Health. 2014 Jul;50(7):504-11. doi: 10.1111/jpc.12497. Epub 2014 Feb 19. DOI: https://doi.org/10.1111/jpc.12497

- Del Pozzo-Magaña BR, Lazo-Langner A, Gutiérrez-Castrellón P, Ruiz-Maldonado R. Common Dermatoses in Children Referred to a Specialized Pediatric Dermatology Service in Mexico: A Comparative Study between Two Decades. ISRN Dermatol. 2012;2012:351603. doi: 10.5402/2012/351603. Epub 2012 Oct 14. DOI: https://doi.org/10.5402/2012/351603

- Inanir I, Sahin MT, Gündüz K, Dinç G, Türel A, Oztürkcan S. Prevalence of skin conditions in primary school children in Turkey: differences based on socioeconomic factors. Pediatr Dermatol. 2002 Jul-Aug;19(4):307-11.. DOI: https://doi.org/10.1046/j.1525-1470.2002.00087.x

- Barth JH, Wojnarowska F, Dawber RP. Is keratosis pilaris another androgen-dependent dermatosis? Clin Exp Dermatol. 1988 Jul;13(4):240-1 DOI: https://doi.org/10.1111/j.1365-2230.1988.tb00688.x

- Garwood JD. Keratosis pilaris. Am Fam Physician. 1978 Feb;17(2):151-2.

- Vipinsha RS, Prathibha CKB, Anandaraman PVS. Āyuṛveda management of keratosis pilaris - a case report. J Complement Integr Med. 2020 Jul 21;18(1):223-230. DOI: https://doi.org/10.1515/jcim-2019-0195

-Pennycook KB, McCready TA. Keratosis Pilaris. 2021 Jul 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan.

-Leong WM, Aw CW. Nilotinib-Induced Keratosis Pilaris. Case Rep Dermatol. 2016 Apr 21;8(1):91-6.. DOI: https://doi.org/10.1159/000445676

- Wang CM, Fleming KF, Hsu S. A case of vemurafenib-induced keratosis pilaris-like eruption. Dermatol Online J. 2012 Apr 15;18(4):7. DOI: https://doi.org/10.5070/D38W90X9ZB

- Bogle MA. Tazarotene 0.05% cream for the treatment of keratosis pilaris. J Am Acad Dermatol 2004; 50:P39. DOI: https://doi.org/10.1016/j.jaad.2003.10.158

- Kechichian E, Jabbour S, El Hachem L, Tomb R, Helou J. Light and Laser Treatments for Keratosis Pilaris: A Systematic Review. Dermatol Surg. 2020 Nov;46(11):1397-1402. DOI: https://doi.org/10.1097/DSS.0000000000002441

Alkhayal, F. A., Bin Fadliah, R., Alasgah, S., Almutiri, R., & Alqubaisy, Y. (2023). Generalized keratosis pilaris induced by testosterone injections in a patient with CHARGE syndrome. Dermatology Reports, 15(2). https://doi.org/10.4081/dr.2023.9661

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