A case of chronic granulomatous disease and acne: is isotretinoin a safe treatment?

Marco Brusasco; Claudio Feliciani; Maria Beatrice de Felici del Giudice

doi:10.4081/dr.2023.9631

We report the case of a patient with chronic granulomatous disease and acne treated with isotretinoin, who developed a diffuse staphylococcal skin infection during the therapy. Chronic granulomatous disease is a rare genetic disorder characterized by an altered innate immunity with an increased risk of potentially lethal bacterial and fungal infections. Although chronic granulomatous disease is rare, acne is a common manifestation in these patients, but there are no data about the gold standard therapy.

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Brusasco, M., Feliciani, C., & de Felici del Giudice, M. B. (2022). A case of chronic granulomatous disease and acne: is isotretinoin a safe treatment?. Dermatology Reports, 15(2). https://doi.org/10.4081/dr.2023.9631