Effects of canary seed on two patients with disseminated granuloma annulare


Published: 23 December 2022
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Treatment of disseminated granuloma annulare (GA) can be challenging and there is no gold standard for treatment. We observed two cases of generalized GA that were treated successfully with canary seed milk despite being resistant to other treatments. Canary seed milk has antioxidant (contains vitamin E), anti-diabetic (DPP-4 inhibition), and anti-hypertensive (ACE inhibition) properties. Therefore, dermatologists can consider canary seed milk, also known as alpiste milk, as a sole or supplemental treatment for patients with GA with or without comorbidities such as diabetes and hypertension, who prefer alternative therapy or failed other treatments.


Wu W, Robinson-Bostom L, Kokkotou E, et al. Dyslipidemia in granuloma annulare: a case-control study. Arch Dermatol 2012;148:1131-6.

Barbieri JS, Rosenbach M, Rodriguez O, Margolis DJ. Association of granuloma annulare with type 2 diabetes, hyperlipidemia, autoimmune disorders, and hematologic malignant neoplasms. JAMA Dermatol 2021;157:817-23.

Wang J, Khachemoune A. Granuloma annulare: a focused review of therapeutic options. Am J Clin Dermatol 2018;19:333-44.

Piette EW, Rosenbach M. Granuloma annulare: pathogenesis, disease associations and triggers, and therapeutic options. J Am Acad Dermatol 2016;75:467-79.

Estrada-Salas PA, Montero-Morán GM, Martínez-Cuevas PP, et al. Characterization of antidiabetic and antihypertensive properties of canary seed (phalaris canariensis l.) peptides. J Agric Food Chem 2014;62:427-33.

Abdel-Aal ESM, Hucl P, Patterson CA, Gray D. Fractionation of hairless canary seed (phalaris canariensis) into starch, protein, and oil. J Agric Food Chem 2010;58:7046-50.

Capuano A, Sportiello L, Maiorino MI, et al. Dipeptidyl peptidase-4 inhibitors in type 2 diabetes therapy--focus on alogliptin. Drug Des Devel Ther 2013;7:989-1001.

Lim SW, Jin JZ, Jin L, et al. Role of dipeptidyl peptidase-4 inhibitors in new-onset diabetes after transplantation. Korean J Intern Med 2015;30:759-70.

Perez Gutierrez RM, Baez EG. Diterpenes from seeds of phalaris canariensis and their PTP1B inhibitory activity and hypoglycemic effects in streptozotocin-induced diabetic mice. J Asian Nat Prod Res 2020;22:603-17.

Perez Gutierrez RM, Madrigales Ahuatzi D, Cruz Victoria T. Inhibition by seeds of phalaris canariensis extracts of key enzymes linked to obesity. Altern Ther Health Med 2016;22:8-14.

Imadojemu S, Rosenbach M. Advances in inflammatory granulomatous skin diseases. Dermatol Clin 2019;37:49-64.

Ames MK, Atkins CE, Pitt B. The renin-angiotensin-aldosterone system and its suppression. J Vet Intern Med 2019;33:2551.

Wang Y, Liu H, McKenzie G, et al. Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med 2010;16:607.

Passos CS, Ribeiro RS, Rosa TS, et al. Cardiovascular and renal effects of birdseed associated with aerobic exercise in rats. Med Sci Sports Exerc 2016;48:1925-34.

Rohrbach MS, Kossard S, Winkelmann RK. Serum angiotensin-converting enzyme in granuloma annulare. Ann Intern Med 1979;90:441.

Ojeda L, Ruiz YD, Martinez F, et al. Effects of the seed of phalaris canariensis and the change of diet on serum lipids in rats. Emir J Food Agr 2021;33:287-92.

Madrigales-Ahuatzi D, Perez-Gutierrez RM. Evaluation of anti-inflammatory activity of seeds of phalaris canariensis. Drug Res (Stuttg) 2016;66:23-7.

Slavin JL, Martini MC, Jacobs DR Jr, Marquart L. Plausible mechanisms for the protectiveness of whole grains. Am J Clin Nutr 1999;70:459S-63S.

Chen Z, Yu L, Wang X, et al. Changes of phenolic profiles and antioxidant activity in canary seed (phalaris canariensis l.) during germination. Food Chem 2016;194:608-18.

Poppe H, Poppe LM, Goebeler M, Trautmann A. Treatment of disseminated granuloma annulare with oral vitamin E: 'primum nil nocere'. Dermatology 2013;227:83-8.

Park, L., Green, C., Arutyunyan, S., Vasile, G., Buckley, C., & Weiss, E. (2022). Effects of canary seed on two patients with disseminated granuloma annulare. Dermatology Reports, 15(2). https://doi.org/10.4081/dr.2023.9614

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