The role of protein-53 amyloid in determining the aggressiveness of basal cell carcinoma regulated by interleukin-6, myeloid cell leukemia-1 and basic fibroblast growth factor


Published: 29 March 2019
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Authors

  • Prasetyadi Mawardi Dermatovenereology Department, Medical Faculty of Sebelas Maret University/Dr. Moewardi Public Hospital, Surakarta, Indonesia.
  • Handono Kalim Internal Medicine Department, Faculty of Medicine Brawijaya University/dr. Saiful Anwar Public Hospital, Malang, Indonesia.
  • Kusworini Handono Kalim Clinical Pathology Department, Faculty of Medicine, Brawijaya University/dr. Saiful Anwar Public Hospital, Malang, Indonesia.
  • Loeki Enggar Fitri Parasitology Department, Faculty of Medicine Brawijaya University/dr. Saiful Anwar Public Hospital, Malang, Indonesia.
  • Karyono Mintarjo Pathology Department, Faculty of Medicine, Brawijaya University/dr. Saiful Anwar Public Hospital, Malang, Indonesia.
  • Ambar Mudigdo Pathology Department, Medical Faculty of Sebelas Maret University/Dr. Moewardi Public Hospital, Surakarta, Indonesia.
  • Oyong Oyong Pathology Department, Medical Faculty of Sebelas Maret University/Dr. Moewardi Public Hospital, Surakarta, Indonesia.
  • Brian Wasita Pathology Department, Medical Faculty of Sebelas Maret University/Dr. Moewardi Public Hospital, Surakarta, Indonesia.

Basal cell carcinoma (BCC) is a common malignant skin tumor that rarely metastasized, although it is often locally destructive and aggressive. The amyloid in BCC is resulted from degenerated epithelial cell through apoptosis caused by activation of p53. Interleukin-6, MCL-1 and bFGF are inflammatory mediators which have important role in angiogenesis. To prove that high expression of p53 amyloid is related to aggressiveness of BCC via the regulation of IL-6, MCL-1 and bFGF expression. Archived specimens from 51 cases diagnosed with Primary BCC. We performed immunohistochemical staining for IL-6, MCL-1, bFGF expression and p53 amyloid deposit. There was a significant difference in the expression of p53 (p = 0.04), amyloid deposits (p = 0.015), P53 amyloid deposits (p = 0.038), IL-6 (p = 0.040), MCL-1 (p = 0.032), bFGF (p = 0.044) in A BCC compared with NA BCC. There were a significant association between MCL-1 and bFGF (p = 0.07) and p53 amyloid with bFGF (p = 0.051). p53 amyloid, IL-6, MCL-1 and bFGF have an important role in BCC aggresivity.


Mawardi, P., Kalim, H., Kalim, K. H., Fitri, L. E., Mintarjo, K., Mudigdo, A., Oyong, O., & Wasita, B. (2019). The role of protein-53 amyloid in determining the aggressiveness of basal cell carcinoma regulated by interleukin-6, myeloid cell leukemia-1 and basic fibroblast growth factor. Dermatology Reports, 11(s1). https://doi.org/10.4081/dr.2019.8012

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