https://doi.org/10.4081/ar.2012.e4

From aging to cancer: a DNA methylation journey

Vol. 3 No. 1 (2012)
Submitted: 22 September 2011
Accepted: 5 November 2011
Published: 15 February 2012
CpG islands, Age-related methylation, Tumour-suppressor genes, Werner syndrome, Cancer.
Abstract Views: 3903
PDF: 1108
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Authors

Natalia Puig
Epigenetics of Cancer and Aging Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Ruben Agrelo
agrelo@pasteur.edu.uy
Epigenetics of Cancer and Aging Laboratory, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Epigenetic gene silencing through DNA promoter hypermethylation is now recognised as a major step in the neoplastic transformation of the cell. The methylation levels of several genes increase with age in normal tissues such as the prostate or colon. Genes like WRN or LMNA that are involved in progeria,a premature aging disease WRN and LMNA, are epigenetically inactivated in cancer. In both aging and cancer, global DNA methylation decreases, potentially accounting for the characteristic genomic instability of these processes. In this review, we will focus on how the accumulation of changes in DNA methylation during aging impact tumourigenesis.

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How to Cite

Puig, N., & Agrelo, R. (2012). From aging to cancer: a DNA methylation journey. Ageing Research, 3(1), e4. https://doi.org/10.4081/ar.2012.e4

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