https://doi.org/10.4081/hmr.v2i5.756
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J-L. Harousseau Tipifarnib in hematologic malignancies

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JL Harousseau
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Farnesyltranferase inhibitors (FTI) are signal transduction inhibitors that block farnesylation of a number of proteins including Ras that are involved in key cellular functions (proliferation,survival and differentiation).1,2 Tipifarnib is a potent inhibitor of farnesyltransferase that is orally bioavailable. Tipifarnib was initially developed with the goal of targeting Ras in cancers with a high incidence of Ras mutations. However, after failure of large clinical trials in solid tumors (pancreas, colon) further development was mainly focused on hematologic malignancies

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Harousseau, J. (2009). J-L. Harousseau Tipifarnib in hematologic malignancies. Hematology Meeting Reports (formerly Haematologica Reports), 2(5). https://doi.org/10.4081/hmr.v2i5.756
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