https://doi.org/10.4081/hmr.v2i5.736
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Zanolimumab (HuMax-CD4®), a fully human monoclonal antibody in clinical development for cutaneous T-cell lymphoma

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C Assaf
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Zanolimumab (HuMax-CD4®; Genmab, Copenhaven, Denmark) is a monoclonal human anti-CD4 antibody and specifically targets Thelper cells as well as CD4+ CTCL tumor cells and at a lower level monocytes and macrophages. Due to the interference with the interaction of the CD4 antigen and the major histocompatibility complex class II-molecule (MHC-II) this antibody is decreasing T-cell activation. In 2 phase II multicenter, prospective, open-label clinical trials the efficiency and safety of this anti-CD4 antibody was determined in relapsed early and advanced staged CTCL patients. 38 patients with MF and 9 patients with SS were treated intravenously with zanolimumab at a dosage of 280 mg or 560 mg for early stage patients and with 280 mg or 980 mg for advanced stage patients.

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Assaf, C. (2009). Zanolimumab (HuMax-CD4®), a fully human monoclonal antibody in clinical development for cutaneous T-cell lymphoma. Hematology Meeting Reports (formerly Haematologica Reports), 2(5). https://doi.org/10.4081/hmr.v2i5.736
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