https://doi.org/10.4081/hmr.v2i5.727
0
0
0
0
Smart Citations
0
0
0
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Chronic lymphocytic leukemia

Authors

F Caligaris-Cappio
support@pagepress.org
Chronic Lymphocytic Leukemia (CLL) is characterized by the expansion of monoclonal CD5+ B lymphocytes that accumulate in lymphoid organs, bone marrow (BM) and peripheral blood (PB). Refined cytogenetic studies are documenting the clinical importance of genetic subtyping CLL. The CLL-specific gene alterations are gradually coming to light thanks to mouse models and to the discovery that microRNA (miRNA) genes frequently reside in hot spots for chromosomal abnormalities in CLL cells: as an miR-15a and miR-16-1 are located at 13q14.3. The emerging view is that the main genetic alterations of CLL entail the deregulation of specific microRNAs (miRNAs) that lead to transcriptional/posttranscriptional abnormalities.

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Crossref
0
Scopus
0
Google Scholar
Europe PMC

Supporting Agencies

How to Cite

Caligaris-Cappio, F. (2009). Chronic lymphocytic leukemia. Hematology Meeting Reports (formerly Haematologica Reports), 2(5). https://doi.org/10.4081/hmr.v2i5.727
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).