https://doi.org/10.4081/hmr.v2i5.717

Myelodysplastic syndromes

Vol. 2 No. 5: New Drugs in Hematology, Bologna, Italy 5-7 October 2008
Published: June 23, 2009
Abstract Views: 197
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M Cazzola
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The incidence of primary myelodysplastic syndromes (MDS) is about 5 per 100,000 persons per year in the general population, but it increases to 20-50 per 100,000 persons per year after 60 years of age. About 25,000 new cases are therefore expected in the Europe each year. The FAB classification has been widely used for defining the different subtypes of MDS. More recently, the World Health Organization (WHO) classification of myeloid neoplasms has proved to be a very useful tool. The WHO classification provides valuable prognostic information and may be used for clinical decision making [Malcovati et al., J Clin Oncol 2005;23:7594-603]. The International Prognostic Scoring System (IPSS)3 – based on the percentage of marrow blasts, the cytogenetic pattern, and the number and degree of cytopenias – is useful for predicting survival and the risk of leukemia. We found that dependency on transfusions has a negative effect on the likelihood of survival [Cazzola & Malcovati, N Engl J Med 2005;352:536-8]. Based on WHO subgroups, karyotype, and transfusion requirement, we defined a time-dependent prognostic scoring system (WPSS) that can be used to predict survival and leukemia progression at any time during the clinical course of the disease. More recently, we showed that bone marrow fibrosis represents an additional independent prognostic factor, as this feature identifies a distinct clinical entity characterized by high transfusion need and poor prognosis.

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Cazzola, M. (2009). Myelodysplastic syndromes. Hematology Meeting Reports (formerly Haematologica Reports), 2(5). https://doi.org/10.4081/hmr.v2i5.717
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