https://doi.org/10.4081/hmr.v1i7.631

Refractory chronic lymphocytic leukemia

Vol. 1 No. 7: Chronic Lymphocytic Leukemia: Achievements and Controversies
Published: June 16, 2009
Abstract Views: 212
PDF: 421
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Giovanni Martinelli
support@pagepress.org
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by the progressive accumulation of monoclonal peripheral B cells in bone marrow, peripheral blood and lymphoid tissues. Median survival is about 10 years but it ranges from less than 3 years to a normal life expectancy. Previously, treatment of patients with CLL was based on the use of alkylating agents such as chlorambucil, with resulted in a complete response rate minor than 10%, with a palliation of symptoms and no impact on survival. The introduction of purine analogs and rituximab in first line have improved the complete remission rate, the overall response rate and OS.

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Supporting Agencies

How to Cite

Martinelli, G. (2009). Refractory chronic lymphocytic leukemia. Hematology Meeting Reports (formerly Haematologica Reports), 1(7). https://doi.org/10.4081/hmr.v1i7.631
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).