https://doi.org/10.4081/hmr.v1i7.631

Refractory chronic lymphocytic leukemia

Vol. 1 No. 7: Chronic Lymphocytic Leukemia: Achievements and Controversies
Published: June 16, 2009
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Giovanni Martinelli
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Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder characterized by the progressive accumulation of monoclonal peripheral B cells in bone marrow, peripheral blood and lymphoid tissues. Median survival is about 10 years but it ranges from less than 3 years to a normal life expectancy. Previously, treatment of patients with CLL was based on the use of alkylating agents such as chlorambucil, with resulted in a complete response rate minor than 10%, with a palliation of symptoms and no impact on survival. The introduction of purine analogs and rituximab in first line have improved the complete remission rate, the overall response rate and OS.

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Martinelli, G. (2009). Refractory chronic lymphocytic leukemia. Hematology Meeting Reports (formerly Haematologica Reports), 1(7). https://doi.org/10.4081/hmr.v1i7.631
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