https://doi.org/10.4081/hmr.v1i3.621

The role of FVIII/VWF concentrates in the treatment of von Willebrand diseasel

Vol. 1 No. 3: von Willebrand disease: an update 80 years after its first description
Published: June 16, 2009
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Authors

Massimo Morfini
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Two are the goals of treatment of bleeding episodes in patients with von Willebrand disease (VWD): to correct the abnormal platelet adhesion due to reduced and/or dysfunctional von Willebrand Factor (VWF) and to increase the low level of Factor VIII (FVIII). Replacement therapy with plasma-derived FVIII/VWF concentrates is required for VWD patients who do not respond to desmopressin. Several factors should be taken into account to design and optimize the replacement therapy of VWD. As for other inherited bleeding disorders, the choice of a specific treatment requires an accurate diagnosis, which is of a particular relevance in VWD because of the heterogeneity of phenotypes.

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Morfini, M. (2009). The role of FVIII/VWF concentrates in the treatment of von Willebrand diseasel. Hematology Meeting Reports (formerly Haematologica Reports), 1(3). https://doi.org/10.4081/hmr.v1i3.621
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