https://doi.org/10.4081/hmr.v2i15.600

Translocation Mechanism in Secondary Leukemias Following Topoisomerase II Poisons

Vol. 2 No. 15: Secondary Leukemias and leukemogenesis Rome, 3-4 November 2006
Published: June 16, 2009
Abstract Views: 311
PDF: 401
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Carolyn A. Felix
support@pagepress.org
Blaine W. Robinson
Giuseppe Germano
Christos P. Kolaris
Leslie J. Raffini
Luca Lo Nigro
Emily Roumm
Maureen D. Megonigal
Diana J. Slater
Ryan J. Whitmarsh
Charles Saginario
Brian D. Lovett
Jolanta Libura
Linda D. Pegram
More than 15 years after observations of an association between a distinct form of leukemia characterized by balanced chromosomal translocations involving band 11q23 and introduction of epipodophyllotoxins into clinical usage for anti-cancer treatment in the late1980s, the translocation mechanism is still debated. Epipodophyllotoxins and other anticancer drugs that have been linked to leukemias with various balanced translocations as a treatment complication share the property of being topoisomerase II poisons. In the early 1990s the MLL (ALL-1, HRX, hTRX1) gene was cloned by several groups at the genomic breakpoint junctions of translocations disrupting chromosome band 11q23. This paper will review evidence in favor of the hypothesis that topoisomerase II cleavage complexes induced by poisons of this enzyme damage DNA directly and lead to translocations in secondary leukemias with MLL translocations.

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Supporting Agencies

How to Cite

Felix, C. A., Robinson, B. W., Germano, G., Kolaris, C. P., Raffini, L. J., Lo Nigro, L., Roumm, E., Megonigal, M. D., Slater, D. J., Whitmarsh, R. J., Saginario, C., Lovett, B. D., Libura, J., & Pegram, L. D. (2009). Translocation Mechanism in Secondary Leukemias Following Topoisomerase II Poisons. Hematology Meeting Reports (formerly Haematologica Reports), 2(15). https://doi.org/10.4081/hmr.v2i15.600
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).