https://doi.org/10.4081/hmr.v3i3.582

Lenalidomide: an emerging option in chronic lymphocytic leukemia

Vol. 3 No. 3: 7th Meeting New Insights in Hematology Venice, Italy, 26-29 April 2009
Published: June 12, 2009
Abstract Views: 175
PDF: 194
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Authors

A Ferrajoli
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SM O’Brien
SM O’Brien
S Faderl1
S Faderl1
WG Wierda
WG Wierda
JM Reuben
JM Reuben
MJ Keating
MJ Keating
Lenalidomide is a thalidomidederivative that has shown clinical activity in multiple myeloma, myelodysplastic syndrome (del5q syndrome) and non-Hodgkin’s lymphomas. It belongs to a class of agents called immunomodulating drugs (IMiDs). In comparison to thalidomide, it is a more potent inhibitor of tumor necrosis factor alpha (TNF-a), while retaining some of its anti-angiogenic properties. Our group became interested in evaluating the therapeutic potential of lenalidomide in chronic lymphocytic leukemia (CLL) while searching for TNF-a and VEGF inhibitors. The rationale for targeting TNF-a and VEGF in CLL is based on our observation that patients with CLL have higher levels of TNF-a and VEGF-R2 than normal subjects and that high levels of these cytokines are associated with more aggressive disease and an inferior outcome.1,2

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Ferrajoli, A., O’Brien, S., O’Brien, S., Faderl1, S., Faderl1, S., Wierda, W., Wierda, W., Reuben, J., Reuben, J., Keating, M., & Keating, M. (2009). Lenalidomide: an emerging option in chronic lymphocytic leukemia. Hematology Meeting Reports (formerly Haematologica Reports), 3(3). https://doi.org/10.4081/hmr.v3i3.582
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