https://doi.org/10.4081/hmr.v3i1.542

Gemcitabine

Vol. 3 No. 1: 2006...2009: Now we know T-cell lymphomas better, Bologna, Italy, 16-18 March 2009
Published: June 11, 2009
Abstract Views: 164
PDF: 178
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Authors

M Tani
support@pagepress.org
L Alinari
A Broccoli
E Derenzini
M Fina
L Gandolfi
E Marchi
C Pellegrini
V Stefoni
F Venturini
PL Zinzani
Gemcitabine (2',2'-difluorodeoxy- cytidine, dFdC) is an analog of deoxycytidine. It is transformed to the active triphosphate (dFdCTP) after intracellular phosphorylation. Gemcitabine monophosphate is inserted into the DNA and inhibits DNA elongation as a false nucleotide. In contrast to other antimetabolites, an additional, altered nucleotide is inserted behind dFdC inhibiting repair mechanisms (masked chain termination).

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How to Cite

Tani, M., Alinari, L., Broccoli, A., Derenzini, E., Fina, M., Gandolfi, L., Marchi, E., Pellegrini, C., Stefoni, V., Venturini, F., & Zinzani, P. (2009). Gemcitabine. Hematology Meeting Reports (formerly Haematologica Reports), 3(1). https://doi.org/10.4081/hmr.v3i1.542
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