https://doi.org/10.4081/hmr.v3i1.541

Forodesine

Vol. 3 No. 1: 2006...2009: Now we know T-cell lymphomas better, Bologna, Italy, 16-18 March 2009
Published: June 11, 2009
Abstract Views: 156
PDF: 120
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

EA Olsen
support@pagepress.org
Forodesine is a potent, selective, transition state inhibitor (i) of the enzyme purine nucleoside phosphorylase (PNP). It’s mechanisms of action is distinct from other purine nucleoside analogues in that forodesine does not act through interaction with nucleic acid. Selective PNPi leads to intracellular accumulation of dGTP in target lymphocytes and subsequent apoptosis. In vitro, Tcell lymphocytes are sensitive to forodesine. Based on these observations, a series of studies in subjects with cutaneous T-cell lymphoma were performed with single agent forodesine.

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Supporting Agencies

How to Cite

Olsen, E. (2009). Forodesine. Hematology Meeting Reports (formerly Haematologica Reports), 3(1). https://doi.org/10.4081/hmr.v3i1.541
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).