Gene expression profiling of peripheral T-cell lymphoma: from bench to bedside

Published: June 11, 2009
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Peripheral T-cell lymphomas (PTCLs) represent approximately 12% of lymphoid neoplasms (1). Their incidence varies among countries, being higher in HTLV-1 endemic areas, such as Southern Japan, Caribbean basin and some USA districts.1 PTCLs are a heterogeneous group of tumors that can be roughly subdivided into specified and not otherwise specified (NOS) forms.2 While the former correspond to distinct but rare entities, often occurring at extra-nodal sites, the latter represent the commonest type of T-cell lymphoma (40-50% of cases), followed by the angioimmunoblastic (AITL) and anaplastic large cell (ALCL) ones.

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Piccaluga, P., Rossi, M., Gazzola, A., Sapienza, M., Mannu, C., Righi, S., Agostinelli, C., Sista, M., & Pileri, S. (2009). Gene expression profiling of peripheral T-cell lymphoma: from bench to bedside. Hematology Meeting Reports (formerly Haematologica Reports), 3(1). https://doi.org/10.4081/hmr.v3i1.528