https://doi.org/10.4081/hmr.v2i13.498

Rationale for the design of combination therapies that are active in T-cell lymphomas?

Vol. 2 No. 13: It’s time to take care of T-Cell Lymphomas Bologna, Italy, 22-24 October 2006
Published: June 10, 2009
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W Plunkett
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The lymphomas are the most diverse group of diseases within any single class of malignancy. More than thirty different clinico-pathologic diseases have been identified and classified. Such a variety of diseases of the lymphoid system likely are the result of the unique etiology of each individual tumor type. On the basis of function, T-cells and B-cells have distinctly different functions, and undoubtedly activate genes to drive the different specialized pathways to achieve these purposes. Factors that clearly have a role in lymphomagenesis include illegitimate gene recombination, infection by oncogenic viruses, impaired host immunity, and persistent proliferation driven by inflammation.

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Plunkett, W. (2009). Rationale for the design of combination therapies that are active in T-cell lymphomas?. Hematology Meeting Reports (formerly Haematologica Reports), 2(13). https://doi.org/10.4081/hmr.v2i13.498
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