https://doi.org/10.4081/hmr.v2i13.490

Alemtuzumab (Campath-1H)

Vol. 2 No. 13: It’s time to take care of T-Cell Lymphomas Bologna, Italy, 22-24 October 2006
Published: June 10, 2009
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Authors

C Querfeld
support@pagepress.org
TM Kuzel
J Guitart
ST Rosen
Monoclonal antibodies (MoAb) augment the host anti-tumor response by selectively targeting the malignant cells. MoAb can mediate anti-tumor effects through three major mechanisms including intrinsic cytotoxic activity, antibody-dependent cellular cytotoxicity (ADCC), and activation of complement-dependent cytolysis. Alemtuzumab is a humanized IgG1 MoAb that targets the glycosylated peptide cell surface antigen CD52 that is abundantly expressed (approximately 500,000 molecules/cell) on normal and malignant B- and T-cells, but not on hemat o poietic stem cells. It was approved by the US Food and Drug Administration (FDA) in 2001 for the treatment of refractory B-cell chronic lymphocytic leukemia (B-CLL).

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Querfeld, C., Kuzel, T., Guitart, J., & Rosen, S. (2009). Alemtuzumab (Campath-1H). Hematology Meeting Reports (formerly Haematologica Reports), 2(13). https://doi.org/10.4081/hmr.v2i13.490
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