https://doi.org/10.4081/hmr.v2i13.482

Phase II trial of romidepsin (FK228 or depsipeptide) in peripheral T-cell lymphoma: clinical activity and molecular markers

Vol. 2 No. 13: It’s time to take care of T-Cell Lymphomas Bologna, Italy, 22-24 October 2006
Published: June 10, 2009
Abstract Views: 211
PDF: 297
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Authors

RL Piekarz
support@pagepress.org
R Frye
M Turner
J Turner
S Allen
MH Kirschbaum
J Zain
M Prince
Histone deacetylase inhibitors induce changes in gene expression that lead to cellular differentiation and reversal of the transformed phenotype. In addition, acetylation of centromeric chromatin and non-histone proteins also likely plays a role in cytotoxicity due to romi depsin. Interest in clinical development of these agents has been spurred by the responses observed in patients with peripheral or cutaneous T-cell lymphoma to romidepsin, previously FK228 or depsipeptide.

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Piekarz, R., Frye, R., Turner, M., Turner, J., Allen, S., Kirschbaum, M., Zain, J., & Prince, M. (2009). Phase II trial of romidepsin (FK228 or depsipeptide) in peripheral T-cell lymphoma: clinical activity and molecular markers. Hematology Meeting Reports (formerly Haematologica Reports), 2(13). https://doi.org/10.4081/hmr.v2i13.482
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